| 硫喷妥钠的催眠作用与受体的关系 |
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| 引用本文： | 李惠萍,裴世成,吴钢,冯艺萍,陈丽,孔靖. 硫喷妥钠的催眠作用与受体的关系[J]. 广西医学, 2007, 29(8): 1152-1153 |
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| 作者姓名： | 李惠萍 裴世成 吴钢 冯艺萍 陈丽 孔靖 |
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| 作者单位： | 柳州医学高等专科学校药理教研室,柳州市,545006;柳州医学高等专科学校药理教研室,柳州市,545006;柳州医学高等专科学校药理教研室,柳州市,545006;柳州医学高等专科学校药理教研室,柳州市,545006;柳州医学高等专科学校药理教研室,柳州市,545006;柳州医学高等专科学校药理教研室,柳州市,545006 |
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| 基金项目： | 广西医疗卫生科研课题(桂卫Z2005199) |
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| 摘 要： | 目的观察硫喷妥钠的催眠作用与甘氨酸和阿片受体的关系。方法腹腔注射硫喷妥钠建立催眠作用的小鼠模型,在催眠实验中,观察士的宁、纳洛酮对硫喷妥钠小鼠翻正反射消失持续时间的影响。结果士的宁、纳洛酮对硫喷妥钠小鼠的睡眠时间均有明显影响(P<0.01)。结论甘氨酸受体和阿片受体均介导了硫喷妥钠的催眠作用。
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| 关 键 词： | 硫喷妥钠 催眠 士的宁 纳洛酮 受体 |
| 文章编号： | 0253-4304（2007）08-1152-02 |
| 修稿时间： | 2007-06-05 |
The relationship between the hypnotic effect of thiopentai sodium and receptor |
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| LI Hui-ping,FEI Shi-cheng,WU Gang,FENG Yi-ping,CHEN Li,KONG Jing. The relationship between the hypnotic effect of thiopentai sodium and receptor[J]. Guangxi Medical Journal, 2007, 29(8): 1152-1153 |
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| Authors: | LI Hui-ping FEI Shi-cheng WU Gang FENG Yi-ping CHEN Li KONG Jing |
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| Affiliation: | Department of Pharmacology, Liuzhou Medical College, Liuzhou 545006, China |
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| Abstract: | Objective To explore the relation between the hypnotic effect of thiopental sodium and glycinebetaine,opioid receptor.Methods The mice model of hypnotic effect was established by intraperitoneal injection of thiopental sodium.In the hypnotic experiments,we observed the effect of Strychnine and naloxone on the the loss of righting reflex in the mice injected with thiopental sodium.Results Strychnine and naloxone had obvious effect on the sleeping time of the mice injected with thiopental sodium (P<0.01).Conclusion Both glycine receptor and opioid receptor mediated hypnotic effect of thiopental sodium. |
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| Keywords: | Thiopental sodium Hypnotic Strychnine Naloxone Receptor |
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