帕罗西汀与阿米替林对烧伤后情绪的疗效比较

目的:研究帕罗西汀与阿米替林对烧伤后情绪的临床疗效和安全性。方法:将57例伴有情绪障碍的烧伤患者随机分为两组,治疗组用帕罗西汀,对照组用阿米替林改善情绪障碍。治疗8周后行汉密尔顿抑郁/焦虑量表(HAMD/HAMA)评分,比较两组的治疗效果;并观察不良事件和副作用的发生。结果:治疗组与对照组治疗前后的HAMD/HAMA评分有显著性差异(P<0.05)。两组治疗后的HAMD/HAMA评分和显效率无显著性差异(P>0.05),但治疗组患者出现不良反应较对照组小。结论:帕罗西汀治疗烧伤后情绪障碍是安全和有效的,阿米替林也有很好的疗效,但副作用较大。

Comparison on the efficacy of paroxetine and amitriptyline in acute burnt patients with psychological disorders

Objective：To investigate the efficacy and safety of paroxetine and amitriptyline on acute burn patients with psychological disorders. Methods： Fifty and seven patients suffered from acute burnt accompanied with depression disorders and/or anxiety disorders were randomly divided in to two groups treated with paroxetine and amitriptyline, respectively. After 8 weeks, the scores of HAMD/HAMA scale of two groups were compared on the treatment efficacy. Results：The scores of HAMD/HAMA scale were significantly different between two groups before and after treatment （P〈0.05） ,while the scores of HAMD/HAMA scale and the effective ratio were not significantly different between two groups after treatment （P〉0. 05） . The adverse effects occurred in tested group was slighter than that in the control group. Conclusion：Paroxetine is effective and safe and should be considered as first-line treatment in burnt patients with depression/anxiety. Amitriptyline also has a good clinical response but the severe complication make it as second-line antidepressant.