影响乳腺癌肝转移患者预后的多因素分析

目的:分析影响乳腺癌肝转移患者的预后因素。方法:回顾分析我院1991年3月-2004年2月收治的26例乳腺癌肝转移患者的临床资料,采用t检验比较多因素对乳腺癌肝转移患者TTP影响的差异。结果:乳腺癌肝转移患者化疗的有效率为53．84％。肝内单一转移灶7人,中位TTP为9．86个月,多个转移灶19人,中位 TTP为6．10个月,P>0．05;不伴有其它远处转移灶10人,中位TTP为5．00个月,伴有其它远处转移灶16人,中位 TTP为9．86个月,P>0．05;肝转移后化疗17人,中位TTP为9．65个月,不化疗9人,中位TTP为2．33个月,P< 0．05。结论:化疗对乳腺癌肝转移患者的预后有明显的影响,肝内转移灶数目和是否伴有其它转移灶对预后影响不明显。

Multivariate Analysis of Prognostic Factors for Breast Cancer Patients with Liver Metastasis

Objectine: To investigate the prognostic factors of breast cancer patients with liver metastasis. Methods: The data of 26 breast cancer patients with liver metastasis treated from Mar 1991 to Feb 2004 were reviewed and analyzed by two sample test. Results:The response rate of chemotherapy was 53. 84% . There were 7 patients with single metastasis in liver and 19 patients with multi-metastasis in liver. The median TTP of patients with single metastasis in liver was 9. 86 months and 6. 10 months in patients with multi-metastasis in liver(P>0.05 ). Among the 26 patients, the median TTP of 10 patients without distant metastasis in other organ was 5 months; 9. 86 months for other 16 patients with distant metastasis in other organs(P>0. 05) , 17 patients received chemotherapy with median TTP of 9. 65 months; 9 patients did not receive chemotherapy and their median TTP was 2. 33 months (P <0. 05). Conclusion: The prognosis of breast cancer with liver metastasis is influenced significantly by chemotherapy but not the mumber of liver metastasis and distant metastasis in other organ.