| 芹菜籽油抗D-半乳糖致衰老模型动物的作用研究 |
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| 引用本文： | 钟敬波,徐成,丁倩,曹颖林.芹菜籽油抗D-半乳糖致衰老模型动物的作用研究[J].中国药房,2008,19(24):1855-1857. |
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| 作者姓名： | 钟敬波 徐成 丁倩 曹颖林 |
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| 作者单位： | 1. 海南省人民医院药学部,海口市,570102
2. 沈阳药科大学药理系,沈阳市,110015 |
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| 摘 要： | 目的:研究芹菜籽油(CSO)抗D-半乳糖致衰老模型动物的作用。方法:分别对小鼠和大鼠皮下注射D-半乳糖复制衰老模型,同时灌胃给予CSO。6周后,通过跳台法和电生理方法观察CSO对衰老模型动物学习记忆的改善,同时比较衰老小鼠脑组织内丙二醛(MDA)含量及单胺氧化酶B(MAO-B)、超氧化物歧化酶(SOD)活性的差异。结果:CSO对衰老动物的学习记忆障碍有显著的改善作用;能显著降低衰老小鼠脑组织内MDA的含量和MAO-B的活性,增加SOD的活性。结论:CSO具有较好的抗衰老作用
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| 关 键 词： | 学习记忆 衰老模型 芹菜籽油 |
Antiaging Effect of Celery Seed Oil on D-galactose-induced Aging Animal Models |
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| ZHONG Jing-bo,XU Cheng,DING Qian,CAO Ying-lin.Antiaging Effect of Celery Seed Oil on D-galactose-induced Aging Animal Models[J].China Pharmacy,2008,19(24):1855-1857. |
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| Authors: | ZHONG Jing-bo XU Cheng DING Qian CAO Ying-lin |
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| Institution: | ZHONG Jing-bo (Dept. of Pharmacy, Hainan Provincial People＇s Hospital, Haikou 570102, China) XU Cheng, DING Qian, CAO Ying-lin(Dept.of Pharmacology, Shenyang Pharmaceutical University, Shenyang 110015, China) |
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| Abstract: | OBJECTIVE： To observe the antiaging effect of celery seed oil （CSO） on aging mice and rats induced by D- galactose. METHODS： Aging models were established with D - galactose hypo. At the same time, the model animals were intragastrically given CSO. After 6 weeks, the effects of CSO on learning and memory were evaluated by step down test and electrophysiological test. And the MDA content, MAO- B and SOD activity in brains of aging mice were measured. RE- SULTS： CSO can markedly improve the learning and memory of aging mice and rats, reduce the content of MDA and activity of MAO-B, and increase SOD activity. CONCLUSION： CSO has good antiaging effect. |
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| Keywords: | Learning and memory Aging models Celery seed oil |
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