中国人群HLA-DRB1基因多态性与慢性乙型肝炎关系的Meta分析

目的:用Meta分析的方法综合评价中国人群HLA-DRB1基因多态性与慢性乙型肝炎的关系.方法:检索中国生物医学文献数据库、维普数据库和Medline数据库,依据选择标准收集所有相关的病例对照研究,应用RevMan4.2软件对符合条件的研究结果进行Meta分析.结果:符合纳入标准的共8篇文献,包含慢性乙型肝炎组501例和正常对照组855例.经综合分析:HLA-DRB1*03和HLA-DRB1*08可能为中国人群慢性乙型肝炎的易感性基因型(OR=2.44,95%CI:1.65-3.61,P<0.00001;OR=1.57,95%CI:1.08-2.28,P=0.02);HLA-DRB1*13和HLA-DRB1*15可能是我国人群慢性乙型肝炎的保护性基因型(OR=0.40,95%CI:0.21-0.79,P=0.008;OR=0.64,95%CI:0.46-0.90,P=0.01).结论:中国人群慢性乙型肝炎的发生与HLADRB1基因的多态性有关,与其他国家人群既有相同点,也有其自身特点.

Meta-analysis on the relationship between HLA-DRB1 gene polymorphism and chronic hepatitis B in Chinese population

AIM: To assess the associations of HLA-DRB1gene polymorphism with chronic hepatitis B inChinese population.METHODS: A comprehensive search for articlesfrom 1998 to 2006 was conducted from Chinese BioMedical Literature Database on disc (CBM-disc), VIP and Medline databases. A total of 8epidemiological case-control studies on the relationship between gene polymorphism of HLA-DRB1 and chronic hepatitis B were performedand the results were analyzed using RevMan 4.2software.RESULTS: A total of 501 patients with chronichepatitis B and 855 uninfected healthy controlswere included from the 8 studies. HLA-DRB1*03 and HLA-DRB1*08 alleles were the risk factors of CHB, the values of pooled odds ratio were 2.44 (95% CI: 1.65-3.61, P < 0.00001) and 1.57 (95% CI: 1.08-2.28, P = 0.02), respectively. HLA-DRB1*13 and HLA-DRB1*15 alleles were the protection factors against CHB, and the values of pooled odds ratio were 0.40 (95% CI: 0.21-0.79, P = 0.008) and 0.64 (95%CI: 0.46-0.90, P = 0.01), respectively.CONCLUSION: The occurrence of CHB is associated with the gene polymorphism of HLA-DRB1 in Chinese population.