埃索美拉唑与奥美拉唑治疗消化性溃疡132例疗效观察

目的比较埃索美拉唑与奥美拉唑三联疗法治疗幽门螺杆菌(Helicobacter pylori,简称Hp)阳性消化性溃疡的效果。方法将确诊为Hp阳性消化性溃疡132例患者随机分为埃索美拉唑组和奥美拉唑组,每组66例。两组分别给予阿莫西林1g,1日2次,克拉霉素0.5g,1日2次,埃索美拉唑组加用埃索美拉唑20mg,1日2次,奥美拉唑组加用奥美拉唑20mg,1日2次。1周后两组分别单用埃索美拉唑20mg,1日1次,奥美拉唑20mg,1日1次,维持治疗3周。两组患者治疗前和治疗后检测Hp状况。结果埃索美拉唑组溃疡愈合率为94.0%,奥美拉唑组溃疡愈合率为90.9%;埃索美拉唑组Hp根除率为92.4%,奥美拉唑组Hp根除率为84.9%。两组比较溃疡愈合率及Hp根除率差异无统计学意义(P>0.05);第1天和第2天腹痛缓解率埃索美拉唑组为36.4%和60.6%,奥美拉唑组为16.7%和33.3%,两组比较差异有统计学意义(P<0.05)。结论埃索美拉唑、阿莫西林、克拉霉素三联疗法治疗Hp感染消化性溃疡优于奥美拉唑、阿莫西林、克拉霉素三联疗法,腹痛缓解较快。

To observe the efficacy of esomeprazole and omeprazole to 132 peptic ulcer patients

Objective To compare the efficacy of triple therapy with esomeprazole or omeprazole to peptic ulcer patients with Helicobacter pylori (H.pylori) infection Methods 132 peptic ulcer patients of H. pylori-positive were randomly divided into esomeprazole group and omeprazole group. Each includes 66 patients.The two groups both received amoxicillin (Am) 1g b.i.d.,clarithromycin 0.5g twice daily(b.i.d.),otherwise the esomeprazole group was given esomeprazole 20mg b.i.d.,the omeprazole group omeprazole 20mg b.i.d.One week later the both group were not administered Am and clarithromycin again,only used tested drugs,esomeprazole and omeprazole,20 mg once a day respectively for three weeks. All groups were detected H. pylori before and after therapy. Results The healing rate of peptic ulcer in esomeprazole and omeprazole group is 94.0% and 90.9% respectively,eradiation rate of H. pylori is 92.4% and 84.9% respectively. There is no significant difference between two groups on not only healing rate but eradication rate(P >0.05).The releasing rates of bellyache on the first and second day were 36.4% and 60.6% in esomeprazole group,these were 16.7% and 33.3% in omeprazole group,the differences had statistically significance(P <0.05). Conclusion Esomeprazole-based triple therapy regimen is a better option in curing peptic ulcer of H.pylori-positive than omeprazole-based treatment,bellyache can be released quickly.