Phosphorylcholine Coating of ePTFE Grafts Reduces Neointimal Hyperplasia in Canine Model |
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| Authors: | Changyi Chen Alan B. Lumsden John C. Ofenloch Beverly Noe Ewan J. Campbell Peter W. Stratford Yiannakis P. Yianni Alistair S. Taylor Stephen R. Hanson |
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| Affiliation: | (1) Department of Surgery, Emory University School of Medicine, Atlanta, GA, US;(2) Department of Medicine, Emory University School of Medicine, Atlanta, GA, US;(3) Cardiovascular Division, Biocompatibles Ltd, Farnham, Surrey, UK, GB |
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| Abstract: | 2 versus 0.53 ± 0.13 mm2, respectively; p= 0.008). Furthermore, the BrdU labeling index in the graft neointimal tissues was significantly smaller (p < 0.001) in the treated group (2.64 ± 0.77%) as compared with the control group (5.07 ± 0.83%). These data demonstrate that PC coating of ePTFE significantly reduces graft neointimal hyperplasia and cell proliferation in a canine carotid artery bypass model. The application of PC within the ePTFE graft effectively blocks tissue ingrowth from the adjacent native vessel, thereby preserving the anastomosis luminal diameter. |
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