小鼠颊癌颈部淋巴结超声造影的实验研究

目的 探讨局部注射造影剂对移植颊癌原发灶及颈部转移淋巴结增强显像效果.方法 建立小鼠颊癌颈部转移淋巴结动物模型后,经原发灶局部注入自制表面活性剂类超声微泡,以谐波显像方式观察原发灶及颈部淋巴结增强显像效果,同时进行回声强度的比较.结果 造影前,转移淋巴结检出率为61%（17/28）,炎性淋巴结检出率为50%（6/12）;造影后转移淋巴结检出率为82%（23/28）,炎性淋巴结检出率为75%（9/12）.与造影前比较,造影后原发灶和淋巴结的回声强度增大,差异有统计学意义（P〈0.01）结论自制表面活性剂类超声微泡能够经原发灶注入,进入淋巴道,实现显著的淋巴结超声显像增强效果.

Experimental study on contrast-enhanced ultrasound imaging of metastatic lymph nodes of cheek carcinoma

Objective To explore the enhancement effect of contrast media on primary cancer and cervical metastatic lymph nodes of cheek carcinoma by local injection. Methods The lymphatic metastasis cheek carcinoma mice models were established, then self-made contrast media was administered into the primary cheek carcinoma, and harmonic mode imaging was performed to observe the enhancement of primary lesions and cervical metastatic lymph nodes. The echo intensity （EI） was compared. Results The decteetion rate of metastatic lymph nodes and inflammatory lymph nodes was 61% （ 17/28 ） and 50% （6/12） before contrast - enhanced ultrasound（CEUS） imaging, while 82% （23/28） and 75% （9/12） after CEUS imaging. After CEUS imaging, the El of primary cancer and cervical metastatic lymph nodes was increased, there was significant difference（ P 〈 0.01 ）. Conclusion After injection of self - made contrast media via the primary lesion, it can enter the lymph duct and obviously enhance the effect of uhrasonography on cervical metastatic lymph nodes of cheek carcinoma.