Effect of captopril treatment on proteinuria in NZB/NZW F1 hybrid mice |
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Authors: | S Kurakata M Fukami K Kitamura |
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Affiliation: | Biological Research Laboratories, Sankyo Co., Ltd., Tokyo, Japan. |
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Abstract: | Oral treatment of female NZB/NZW F1 hybrid mice with captopril prevented the development of proteinuria and prolonged survival in mice demonstrating slight (trace to 1+) proteinuria. Captopril treatment also markedly reduced the incidence and magnitude of proteinuria and prevented death in mice showing significant (3+ or greater) proteinuria. Histopathological studies of the kidneys of treated mice further demonstrated improvements in the renal lesions of autoimmune mice. The mechanisms whereby captopril treatment influences the course of disease in NZB/NZW mice are not known. |
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