含二氯二甲基海因复方消毒剂性能的试验观察

含二氯二甲基海因复方消毒剂的辅助成分有甲基海因、溴化钾．十二烷基硫酸钠．硅酸钠、三聚磷酸钠、无水硫酸钠等,100g粉剂中含有效氯≥33g。为了解其杀菌效果、稳定性与毒性,进行了悬液定量杀菌试验、热稳定性试验与毒性试验。结果,在18~22℃下,对悬液中金黄色葡萄球菌以其含有效氯50mg/L溶液作用15min,对大肠杆菌以其含有效氯20mg/L溶液作用15min,对枯草杆菌黑色变种芽胞以其含有效氯800 mg/L溶液作用60min,杀灭率均达100%。有机物对其杀菌效果有一定影响。该剂于54℃存放14d,有效氯含量下降率＜1．24%。该剂水溶液对小鼠经口灌胃LD50,为2489mg/kg。对家兔皮肤刺激反应积分为0,小鼠蓄积系数K＞5,小鼠骨髓微核试验阴性。因此,该复方为杀菌效果与稳定性较好,毒性较低的消毒剂。

EXPERIMENTAL OBSERVATION ON PROPERTIES OF COMPOUND DISINFECTANT CONTAINING DICHLORODIMETHYL HYDANTOIN

The adjuvant ingredients of the compound disinfectant containing dichlorodimcthyl hydanloin arc methyl hydantoin, potassium bromide, sodium dodecyl sulfatc, sodium silicate, sodium tripolyphosphate, anhyrous sodium sulfatc, etc.. 100 g of powder contains available chlorine =33 g. In order to know its gcrmicidal efficacy, stability and toxicity, suspension quantitative germicidal test, thermostabilily lest and toxicily test were carried out. The results showed that at 18~ 22癈 , the killing rates of Staphylococcus aureus in suspension exposed to its solution containing available chlorine 50 mg/ L for 15 min, Escherichia coli exposed to its solution containing available chlorine 20 mg / L for 15 min and spores of Bacillus subtilis var. niger exposed to its solution containing available chlorine 800 mg/ L for 60 min were 100%. The organic substances had certain influence on its germicidal efficacy. After storing it at 54癈 for 14 days, its available chlorine content decreased by <1.24%. The oral LD50 of its water solution in mice was 2 489 mg/ kg. The rabbit skin irrtation reaction score was 0, the mouse accumulation coefficient K was >5 and the mouse bone marrow micronucleus lest was nega tive. Therefore, this compound disinfectant is a disinfeclant with good germicidal efficacy and stability and low toxicity.