高血压左室肥厚与动态血压变异性的关系

目的研究高血压(EH)患者左室肥厚(LVH)与动态血压监测参数:血压变异性(BPV)的关系.方法75例高血压病人,平均年龄63±8岁.动态测定24h血压;超声心动图测室间膈、左室后壁厚度、左室舒张末直径,并按Devereux校正公式计算左心室重量指数(LVMI);根据LVMI的结果分为LVH组和无LVH组.结果动态血压变异系数:24h收缩压变异系数、夜间收缩压变异系数在LVH组(0.0830±0.0076,0.1149±0.2537)明显低于无LVH组(0.2677 0.1524,0.3573 0.3667)(P＜0.01);LVH组的LVMI 分别与24h收缩压变异系数、24h舒张压变异系数、夜间收缩压变异系数、夜间舒张压变异系数呈负相关.结论伴LVH的EH患者心血管交感、迷走神经功能失衡;BPV可能对EH患者靶器官损害有预测价值.

The Relation between Left Ventricular Hypertrophy and Blood Pressure Variability in Hypertensive Patients

Objective To explore the relation between left ventricular hypertrophy (LVH) and the parameter of ambulatory blood pressure monitoring (ABPM) , blood pressure variability, in hypertensive patients. Methods 75 essential hypertensive patients were selected. The ambulatory blood pressure was measured for 24 hours and the left ventricular mass indexes (LVMI) were measured with echocardiography according to Devereux's correction formula. Results The 24 hrs SBPV in essential hypertension (EH) patients with LVH were significantly lower than that in EH patients without LVH (P < 0. 01). Left ventricular mass indexes (LVMI) in EH patients with LVH were correlated negatively with 24hrs SBPV, 24hDBPV, nSBPV and nDBPV, respectively. Conclusions The study suggests that the cardiovascular sympathovagal balance is impaired in EH patients with LVH. The BPV of EH patients may be associated with the degree of target organ damage.