小肠绒毛微循环的血流动力学体外研究

目的：对造成小肠绒毛易损伤的血流动力学机制进行研究。方法：根据小肠绒毛微血管结构设计制作了体外模型，建立一套模拟体循环系统。在不同的体循环状态下模型中的流量和压力被在线测量。结果：微血管内压力及流量的变化与体循环压变化呈正相关关系；当体循环压降低时，绒毛顶部毛细血管的流量和压力较绒毛底部和中部减少的幅度更大；当体循环压升高时，绒毛顶部毛细血管的流量和压力较绒毛底部和中部增加的幅度更小。结论：当体循

Simulation study of hemodynamic of small intestinal villosity microvessels in vitro

AIM: To study the dynamic mechanism of villosity injury.METHODS: A small intestinal villosity microvessels model and a circulatory simulation system were made. The flow volume and pressure in microvessels model were measured under different systemic circulatory state. RESULTS: The flow volume in model was closely related to systemic circulatory pressure. As the systemic circulatory pressure reduced, the volume and pressure of top capillaries in network decreased much more than that of the middle and bottom capillasies. As the systemic circulatory pressure increased, the volume and pressure of top capillaries in network increased much less than that of the middle and bottom capillasies. CONCLUSION: The top capillaries in network were much more sensitive than middle and bottom capillarise when the systemic circulatory pressure was fell. The microvessels structure of villosity is a special, easy ischemia-injuring structure.