牛磺酸和甘糖酯对糖尿病大鼠自由基防御机能和肾脏功能的影响

目的：探讨牛磺酸和甘糖酯对糖尿病（ＤＭ）大鼠体内自由基防御机能和肾功能的影响。方法：牛磺酸（３００ｍｇ／ｋｇ ＢＷ）甘糖酯（１００ｍｇ／ｋｇ ＢＷ）给予ＤＭ大鼠３周后，检查体内抗氧化酶活性，抗氧化物质水平和肾脏功能。

Effects of taurine and proglylene glucol mannate sulfate on defensive function against free radicals and renal function in diabetic rats

AIM:To explore the effects of taurine and proglylene glucol mannate sulfate (PGMS) on defensive function against free radicals and renal function.METHODS:Taurine (300 mg/kg BW) and PGMS (100 mg/kg BW) were administrated to diabetic rats for 3 weeks and the defensive function against free radicals and renal function were examined. RESULTS:GSH content, activities of SOD and CAT(catalase) in erythrocytes and CAT activity in renal cortex decreased markedly and LPO levels in erythrocytes, serum and renal cortex increased significantly in diabetic rats compared with controls. In taurine-treated diabetic rats, GSH content, activities of SOD and CAT in erythrocytes, and CAT activity in renal cortex were higher, while levels of LPO in erythrocytes,serum and renal cortex were lower than those in untreated diabetic rats. PGMS administration to diabetic animals increased GSH content and CAT activity in erythrocytes and reduced levels of LPO in serum and renal cortex. Taurine-and PGMS-treated diabetic rats exhibited reduction in both blood urea nitrogen content and urinary protein excretion. CONCLUSION:Taurine and PGMS reverse, in part, the disorder of free radical metabolism and the lesion of renal function in diabetic rats.