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| 钙调素在豚鼠过敏性哮喘发病过程中的作用 | |
| 引用本文： | 孙宝君,黄念秋,范明,王瑞红,刘淑红,甘思德.钙调素在豚鼠过敏性哮喘发病过程中的作用[J].中国病理生理杂志,1999,15(1):69-71. |
| 作者姓名： | 孙宝君 黄念秋 范明 王瑞红 刘淑红 甘思德 |
| 作者单位： | 1. 解放军总医院,北京100853 2. 军事医学科学院基础医学研究所 3. 北京师范大学生物系 |
| 摘 要： | 目的和方法：给致敏豚鼠吸入卵蛋白建立速发型过敏性哮喘的动物模型，观察呼吸系总阻抗（ＲＩ）及豚鼠支气管平滑肌钙调素（ＣａＭ）活性的变化。结果：哮喘组ＲＩ明显高于正常组（Ｐ〈０．０１），支气管平滑肌ＣａＭ活性低于正常组（Ｐ〈０．０５），山莨菪碱（６５４－２）有增加支气管平滑肌ＣａＭ活性的作用，异搏定对其无影响。结论：支气管平滑肌ＣａＭ活性下降在哮喘的发病过程中起重要作用。 |
| 关 键 词： | 钙调素 哮喘 过敏性哮喘 豚鼠 |
The role of calmodulin in the pathogenesis of allergic asthma in guinea pig |
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| SUN Bao-Jun,HUANG Nian-Qiu,FAN Ming,WANG Rui-Hong,LIU Shu-Hong,GAN Si-De.The role of calmodulin in the pathogenesis of allergic asthma in guinea pig[J].Chinese Journal of Pathophysiology,1999,15(1):69-71. | |
| Authors: | SUN Bao-Jun HUANG Nian-Qiu FAN Ming WANG Rui-Hong LIU Shu-Hong GAN Si-De |
| Abstract: | AIM and METHODS:The immediate-type allergic asthma animal model was established in sensitized guinea pigs by inhalation with ovalbumin. Respiratory impedance (RI) and the calmodulin activity in bronchial smooth muscle were observed.RESULTS:RI was increased ( P <0.01), while calmodulin activity in brochial smooth muscle was decreased ( P <0.05) in asthma group than that in normal group. Anisodamin(654-2) can increase calmodulin activity in bronchial smooth muscle. Verapamil has no effect on it. CONCLUSION: The decrease of calmodulin activity in bronchial smooth muscle may play an important role in the pathogenesis of the allergic asthma. |
| Keywords: | Calmodulin Asthma Verapamil |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |