ORIGINAL ARTICLE: Investigating the inhibitory activity of green coffee and cacao bean extracts on pancreatic lipase |
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Authors: | S. Almoosawi G. J. McDougall L. Fyfe E. A. S. Al‐Dujaili |
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Affiliation: | 1. Department of Dietetics, Nutrition and Biological Sciences, Queen Margaret University, Edinburgh, UK;2. Scottish Crop Research Institute, Invergowrie, Dundee, UK |
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Abstract: | The present study investigated the effects of green coffee bean extract and Theobroma cacao bean extract on pancreatic lipase activity in vitro. Green coffee bean extract produced a J‐shaped dose‐dependent inhibition of pancreatic lipase with the percentage inhibition of pancreatic lipase ranging from 11.8% to 61.5%. Similar concentrations of Theobroma cacao failed to produce any effect on pancreatic lipase. Non‐linear regression analysis revealed that the concentration of green coffee bean extract required to elicit a 50% inhibition of pancreatic lipase activity (IC50) was approximately 43 µM. In conclusion, extracts of green coffee beans but not Theobroma cacao possess potent inhibitory activity against pancreatic lipase. |
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Keywords: | green coffee bean extract pancreatic lipase polyphenols Theobroma cacao |
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