Predictive value of definitely abnormal general movements in the general population |
| |
Authors: | HYLCO BOUWSTRA GEERTEKE R DIJK‐STIGTER HEDWIG MJ GROOTEN FEMKE EM JANSSEN‐PLAS ALICE J KOOPMANS CHRISTIEN D MULDER ANS Van BELLE MIJNA HADDERS‐ALGRA |
| |
Affiliation: | 1. Beatrix Children’s Hospital – Developmental Neurology, University Medical Centre Groningen, Groningen, the Netherlands;2. Icare, Ouder‐ en Kindzorg, Meppel, the Netherlands;3. Thuiszorg Groningen & GGD, Groningen, the Netherlands;4. GGD Fryslan, Leeuwarden, the Netherlands. |
| |
Abstract: | Aim Definitely abnormal general movements in populations of high‐risk infants predict serious neurodevelopmental impairment. This study aimed to assess predictive values of definitely abnormal general movements at 3 months for serious neurodevelopmental impairment in a representative sample of the general population. Method A prospective cohort study of 455 3‐month‐old infants was performed (241 females, 214 males; mean birthweight 3452g, SD 604g; mean gestational age 39.4wks, SD 1.96; n=32 born preterm). At enrolment, general movement quality was assessed by means of video recording. At 4 years, all participants were reassessed by well‐baby health clinicians; if serious neurodevelopmental impairment was identified, clinical records were reviewed. Predictive values of definitely abnormal general movement quality for major neurodevelopmental impairment were calculated. Results Five children were diagnosed as having a major neurodevelopmental disorder with serious implications for daily life, including three children with cerebral palsy (CP). Three out of the five had shown definitely abnormal general movements; they had lesions involving the periventricular white matter. Two children did not show definitely abnormal general movements; one had unilateral spastic CP due to a cortical lesion and the other had ataxia due to cerebellar atrophy. The positive predictive value of definitely abnormal general movements for major neurodevelopmental impairment was 18/100, and for CP it was 12/100. Negative predictive values approached 100%. Interpretation The good predictive value of general movement assessment in high‐risk populations cannot be generalized to the general population. |
| |
Keywords: | |
|
|