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Milk Fat Globule-EGF Factor 8, Secreted by Mesenchymal Stem Cells,Protects Against Liver Fibrosis in Mice |
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| Authors: | Su Yeon An Yu Jin Jang Hee-Joung Lim Jiyou Han Jaehun Lee Gyunggyu Lee Ji Young Park Seo-Young Park Ji Hyang Kim Byung-Rok Do Choongseong Han Hee-Kyung Park Ok-Hee Kim Myeong Jun Song Say-June Kim Jong-Hoon Kim |
| Affiliation: | 1. Laboratory of Stem Cells and Tissue Regeneration, Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, Republic of Korea;2. Biotechnology Research Institute, HurimBioCell Inc., Seoul, Republic of Korea;3. Department of Oral Medicine and Oral Diagnosis, Seoul National University Dental Hospital, School of Dentistry and Dental Research Institute, Seoul National University, Seoul, Republic of Korea;4. Nexel, Co., Ltd, Seoul, Republic of Korea;5. Department of Surgery, Daejeon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Daejeon, Republic of Korea;6. Division of Hepatology, Department of Internal Medicine, Daejeon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Daejeon, Republic of Korea |
| Abstract: | |
| Keywords: | Mouse Model Signal Transduction MMP Decorin MSC mesenchymal stem/stromal cell ECM extracellular matrix TGF transforming growth factor HSCs hepatic stellate cells MMPs matrix metalloproteinases TIMPs tissue inhibitors of metalloproteinases UCMSCs umbilical cord-derived mesenchymal stem cells hpUCMSCs UCMSCs primed by hepatic differentiation MFGE8 milk fat globule-EGF factor 8 IMDM Iscove’s modified Dulbecco’s medium EGF epidermal growth factor FBS fetal bovine serum PEDF pigment epithelium-derived factor α-SMA α-smooth muscle actin ALB albumin TAA thioacetamide PCR polymerase chain reaction scrtm secretome carbon tetrachloride |
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