HBeAg阳性慢性乙型肝炎病毒携带者中医证型与HBV DNA的关系

目的研究HBeAg阳性慢性乙型肝炎病毒(HBV)携带者的中医证型及病性与HBV DNA的关系。方法将185例HBeAg阳性慢性HBV携带者中医证型概括为单一证型(肝气郁结,肝肾亏虚,脾肾亏虚,湿热内蕴,瘀血阻络)、复合证型和无证可辨型。病性划分为实证、虚证及虚实夹杂证。同时检测其血清HBVDNA水平,并分析其与中医证型及病性的关系。结果无证可辨型、单一证型及复合证型之间HBV DNA无统计学差异(F=0.910,P=0.404)。单一证型之内的不同证型之间HBV DNA亦无统计学差异(χ2=4.672,P=0.323)。不同病性之间HBV DNA无统计学差异(F=0.631,P=0.596)。结论 HBV DNA不宜作为HBeAg阳性慢性HBV携带者中医证型的微观辨证指标。

Relationship between traditional Chinese medicine syndrome types and serum HBV DNA level in chronic HBV carriers positive for HBeAg

Objective To explore the relationship between the syndrome types in traditional Chinese medicine(TCM) and serum HBV DNA load in chronic HBV carriers positive for HBeAg.Methods According to the TCM syndrome types,185 chronic HBV carriers with HBeAg positivity were classified into single syndrome group(liver Qi depression,kidney Qi deficiency,spleen Qi deficiency,and kidney Yang deficiency),compound syndrome group,and unidentifiable syndrome group;based on the nature of the condition in TCM terms,the patients were classified into excess syndrome group,deficiency syndrome group and comorbidity syndrome group.The serum HBV DNA levels in these cases were analyzed in relation to the TCM syndrome types and disease nature.Results HBV DNA levels showed no significant difference among the patients with single syndrome,compound syndromes and unidentifiable syndrome(F=0.910,P=0.404),nor among the patients with the 5 different single TCM syndromes(χ2=4.672,P=0.323) or those with different disease nature(F=0.631,P=0.596).Conclusion Serum HBV DNA level can not be considered as the evidence for syndrome differentiation in chronic HBV carriers with positive HBeAg.