盐酸安罗替尼不良反应文献分析

目的：分析安罗替尼药品不良反应（adverse drug reaction，ADR）的发生规律及特点，为临床安全用药提供参考。方法：检索中国学术期刊全文数据库、维普中文科技期刊数据库、PubMed、Embase及SCI数据库收载的安罗替尼致ADR的个案报道，进行分析。结果：安罗替尼致ADR的文献报道有13篇，共17例，其中男性10例（58.82%），女性7例（41.18%）；年龄主要集中在41岁以上（88.24%）；多发生在用药31~60 d （38.10%）；ADR以心血管系统（33.33%）和呼吸系统（28.57%）损害为主；ADR主要表现为支气管瘘（5例），高血压（4例），手足皮肤反应（2例）等；经对症处理后，13例患者好转，4例患者死亡。结论：应加强安罗替尼ADR的临床监测，避免严重的ADR发生，确保临床安全用药。

Literature analysis of adverse drug reactions induced by anlotinib

OBJECTIVE To explore the general patterns and characteristics of ADRs induced by anlotinib and provide references for clinical application. METHODS ADRs induced by anlotinib reported in foreign and domestic academic journals were retrieved from the databases of CNKI,VIP,PubMed,Embase and SCI and analyzed in depth. RESULTS There were 17 cases from 13 articles of apatinib ADRs reported in the literature,including 10 males(58.82%) and 6 females(41.18%).The incidence of ADRs was higher in patients aged over 41 years(88.24%).Most cases occurred within 31~60 days after drug dosing(38.10%).Damage to cardiovascular system(33.33%) and respiratory system(28.57%) were the most common.The major manifestations of ADRs were bronchial fistula(n=5),hypertension(n=4) and hand-foot skin reaction(n=2).Thirteen patients resolved and 4 deaths occurred after treatment. CONCLUSION The clinical monitoring of ADRs induced by anlotinib should be strengthened to avoid the occurrence of serious ADR and ensure the clinical safety of drug dosing.