Evaluation of the impact of 13-valent pneumococcal conjugate vaccine immunization in children by surveillance of culture-confirmed pneumococcal disease: A prospective clinical microbiological study |
| |
| Affiliation: | 1. Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan;2. Graduate Institute of Clinical Medical Sciences, Chang Gung University College of Medicine, Taoyuan, Taiwan;3. Department of Laboratory Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan;4. Molecular Infectious Disease Research Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan;5. Division of Pulmonary and Critical Care Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan;6. Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan;1. Centre for Medical Parasitology at Department of International Health, Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark;2. Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark;3. Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark;4. LIONEX Diagnostics & Therapeutics GmbH, 38126 Braunschweig, Germany;5. Centre National de Recherche et de Formation sur le Paludisme, BP 2208, Ouagadougou 01, Burkina Faso;6. ASAREN 01BP3916, Ouagadougou 01, Burkina Faso;7. Institut Pasteur, 28 rue du Dr Roux, 75015 Paris, France;8. Biochemistry Department, University of Lausanne, 1066 Epalinges, Switzerland;1. Department of Pediatrics, Chang Gung Memorial Hospital, Keelung Branch, Keelung, Taiwan;2. Chang Gung University College of Medicine, Taoyuan, Taiwan;3. Molecular Infectious Disease Research Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan;4. Department of Laboratory Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan;5. Division of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Children''s Hospital, Taoyuan, Taiwan;1. Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan;2. Department of Psychiatry, Kaohsiung Medical University Hospital, Department of Psychiatry, Faculty of Medicine, Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, 833, Taiwan;1. Instituto Biomédico, Universidade Federal Fluminense, Rua Professor Hernani Melo, 101. São Domingos, Niterói, RJ 24210-130, Brazil;2. Faculdade de Medicina, Universidade Federal Fluminense, Av. Marquês do Paraná, 303. Centro, Niterói, RJ 24033-900, Brazil;3. Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Av. Carlos Chagas Filho, 373 – bloco I, Cidade Universitária, Ilha do Fundão, Rio de Janeiro, RJ 21941-902, Brazil;4. Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, 530E Li Ka Shing Center, Berkeley, CA 94720, USA;1. Children’s Faculty Hospital Košice, Department of Pediatric Infectious Diseases, Košice, Slovakia;2. Charles University, Faculty of Medicine in Hradec Kralove, Department of Social Medicine, Hradec Kralove, Czech Republic;3. Great Ormond Street Institute of Child Health, University College London, London, United Kingdom;4. Biovomed, Hradec Kralove, Czech Republic;5. University Hospital, Department of Infectious Diseases, Hradec Kralove, Czech Republic |
| |
| Abstract: | The study aimed to investigate the impact of 13-valent pneumococcal conjugate vaccine (PCV13) immunization on the overall pneumococcal disease in children in Taiwan by surveillance of culture-confirmed pneumococcal disease (CCPD). This study was conducted in a medical center from 2012 to 2016. Clinical isolates of Streptococcus pneumoniae were prospectively collected from pediatric patients. Serotyping, multi-locus sequence typing, and antimicrobial susceptibility testing were performed. A total of 473 patients with CCPD, including 58 with invasive pneumococcal disease (IPD), were identified. The incidence of CCPD per 10,000 admissions decreased from 71.7 in 2012 to 27.0 in 2016. The proportion of additional PCV13 serotypes significantly decreased from 52.0% in 2012 to 21.7% in 2015 but increased slightly to 26.7% because of serotype 19A in 2016 (P < 0.0001). The proportion of non-vaccine serotypes (NVTs) increased significantly from 18.4% in 2012 to 66.7% in 2016, but the increase of the incidence of CCPD caused by NVTs was not considered significant (P = 0.0885). Genotyping identified predominant clones, ST6315A, ST8315B, and ST166/33823A, for major NVTs. The penicillin non-susceptibility of PCV13 serotypes was significantly higher than that of NVTs (P < 0.0001). Surveillance of CCPD appears superior to IPD alone for evaluation of the overall impact of pneumococcal immunization. Serotype replacement occurred quickly after the use of PCV13, while the incidence of NVT infection did not show a significant increase in children over the years. The gradual introduction of PCV13 into national immunization program is effective in reducing overall pneumococcal disease in children. |
| |
| Keywords: | Children Surveillance Impact 13-valent pneumococcal Conjugate vaccine Culture-confirmed pneumococcal disease Serotype |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
