| 吸入粉雾剂的喷雾工艺及表征研究进展 |
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| 引用本文： | 马银玲,刘红星,鲍亚然,张淑珍,赵锋. 吸入粉雾剂的喷雾工艺及表征研究进展[J]. 中国医院药学杂志, 2021, 41(13): 1362-1365. DOI: 10.13286/j.1001-5213.2021.13.17 |
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| 作者姓名： | 马银玲 刘红星 鲍亚然 张淑珍 赵锋 |
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| 作者单位： | 1. 河北医科大学药学院药剂学教研室, 河北 石家庄;2. 河北省人民医院药学部, 河北 石家庄 050051;3. 内蒙古医科大学第二附属医院科研科, 内蒙古 呼和浩特 010030 |
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| 基金项目： | 河北省自然科学基金项目（编号：H2020307043）;河北省卫生厅医学科学研究重点课题（编号：20170472）;河北医科大学大学生创新性实验计划项目（编号：USIP2020050、USIP2020143） |
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| 摘 要： | 吸入粉雾剂是改善肺部疾病治疗的研究热点,具有上市产品多、生产工艺成熟、颗粒影响因素多、晶型转化因素多、颗粒表面物性变化等特点.目前,吸入粉雾剂存在产品效用、贮藏及生产工艺因素的关联研究不系统等问题,本文对近年来肺部吸入粉雾剂制备新技术(喷雾冷冻干燥技术、微流控-喷雾技术、模板打印技术)及粉体颗粒物理化学表征新技术(反向...
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| 关 键 词： | 喷雾干燥 吸入粉雾剂 制备工艺 颗粒表征 |
| 收稿时间： | 2021-02-25 |
Research advances on spraying technology and characterization of dry powder inhalations |
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| MA Yin-ling,LIU Hong-xing,BAO Ya-ran,ZHANG Shu-zhen,ZHAO Feng. Research advances on spraying technology and characterization of dry powder inhalations[J]. Chinese Journal of Hospital Pharmacy, 2021, 41(13): 1362-1365. DOI: 10.13286/j.1001-5213.2021.13.17 |
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| Authors: | MA Yin-ling LIU Hong-xing BAO Ya-ran ZHANG Shu-zhen ZHAO Feng |
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| Affiliation: | 1. Department of Pharmaceutics, School of Pharmacy, Hebei medical University, Hebei Shijiazhuang 050017, China;2. Department of Pharmacy, Hebei General Hospital, Hebei Shijiazhuang 050051, China;3. Department of Scientific Research, Second Affiliated Hospital, Inner Mongolia Medical University, Inner Mongolia Hohhot 010030, China |
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| Abstract: | Inhaled powder aerosol has been a research hotspot in improving the treatment of lung diseases. It has the unique characteristics of diverse marketed products, mature production process, multiple influencing factors of particles and crystal transformation and varations in particle surface properties. Currently there are some outstanding problems in the study of inhalation powder aerosol, such as product effectiveness, correlation between storage and production process factors, and so on. This review introduced new technologies for preparing inhalation powder aerosols, such as spray freeze drying, microfluidic spray, template printing and physicochemical characterization of powder particles, including reverse gas chromatography, atomic force microscopy, energy dispersive X-ray and time-of-flight ion mass spectrometry to provide rationales for the development of inhaled powder aerosol. |
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| Keywords: | spray drying inhalation powder preparation process particle characterization |
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