Anal human papillomavirus infections in young unvaccinated men who have sex with men attending a sexual health clinic for HPV vaccination in Melbourne,Australia |
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| Institution: | 1. Melbourne Sexual Health Centre, Alfred Health, Melbourne, VIC, Australia;2. Central Clinical School, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, VIC, Australia;3. Murdoch Children’s Research Institute, Parkville, VIC, Australia;4. Centre for Women’s Infectious Disease Research, The Royal Women''s Hospital, Parkville, VIC, Australia;5. Department of Obstetrics Gynaecology, University of Melbourne, Parkville, VIC, Australia;1. Institute of Veterinary Immunology & Engineering, Jiangsu Academy of Agricultural Sciences, Nanjing, Jiangsu 210014, China;2. National Research Center of Engineering and Technology for Veterinary Biologicals, Jiangsu Academy of Agricultural Sciences, Nanjing, Jiangsu 210014, China;3. Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, China;4. Jiangsu Key Laboratory for Food Quality and Safety-State Key Laboratory Cultivation Base, Ministry of Science and Technology Nanjing, Jiangsu 210014, China;5. Shandong Provincial Center for Animal Disease Control and Prevention, Jinan, Shandong 250022, China;1. Department of Epidemiology, Key Laboratory of Public Health Safety (Ministry of Education), Fudan University School of Public Health, Shanghai 200032, China;2. Department of Epidemiology, School of Public Health, University of Michigan, 1415 Washington Heights, Ann Arbor, MI 48109, USA;3. Department of Internal Medicine, Division of Infectious Disease, University of Michigan Medical School, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA;4. Department of Viral Hepatitis Control and Prevention, Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, China;1. Royal Centre for Disease Control, Ministry of Health, Royal Government of Bhutan, Wangchutaba, Serbithang, Thimphu, Bhutan;2. World Health Organization Consultant, C/Juan de Austria, 13, 28010 Madrid, Spain;3. Ministry of Health, Royal Government of Bhutan, P.O. Box: 726, Kawajangsa, Thimphu, Bhutan;4. Global Immunization Division, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, United States;5. Expanded Programme on Immunization, World Health Organization, 20 Avenue Appia, 1211 Geneva, Switzerland;1. Food Animal Health Research Program, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, OH, USA;2. Poultry Diseases Department, Faculty of Veterinary Medicine, Cairo University, Cairo, Egypt;3. Division of Infectious Diseases, Cincinnati Children''s Hospital Medical Center, Cincinnati, OH, USA;4. Department of Veterinary Preventive Medicine, College of Veterinary Medicine, The Ohio State University, Columbus, OH, USA;1. Department of Medicine, Mackay Medical College, New Taipei City, Taiwan;2. Institute of Biomedical Sciences, Mackay Medical College, New Taipei City, Taiwan;3. Medical Research Department, Mackay Memorial Hospital, New Taipei City, Taiwan;4. Institute of Molecular Medicine, National Taiwan University College of Medicine, Taipei, Taiwan;5. Department of Gastroenterology, Buddhist Tzu Chi General Hospital Taipei Branch, New Taipei City, Taiwan;1. Department of Medical Laboratory Science, Faculty of Health Sciences, University of Botswana, Gaborone, Botswana;2. Botswana National Health Laboratory, Gaborone, Botswana;3. Centers for Disease Control and Prevention, Atlanta, GA, USA;4. The Children''s Hospital of Philadelphia, USA;5. Botswana-UPenn Partnership, Gaborone, Botswana;6. Botswana-Harvard AIDS Institute Partnership, Gaborone, Botswana;7. WHO Regional Rotavirus Reference Laboratory, Diarrhoeal Pathogens Research Unit, Sefako Makgatho Health Sciences University, South Africa;8. WHO IST East and Southern Africa, Harare, Zimbabwe;9. McMaster University, Hamilton, Canada;10. African Rotavirus Surveillance Network, Immunization, Vaccines and Development Cluster, WHO African Regional Office, Brazzaville, Congo;11. University of British Columbia, Vancouver, Canada |
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| Abstract: | The Victorian Government introduced a time-limited quadrivalent human papillomavirus (HPV) vaccination catch-up program targeting gay and bisexual men who have sex with men (MSM) aged up to 26 years in 2017. As of 2017, men aged ≥20 years were not eligible for the school-based HPV vaccination program. This study examined the prevalence of anal HPV among 496 MSM aged 20–26 years before they received the first dose of the HPV vaccine at the Melbourne Sexual Health Centre, Australia. More than half (56.5%) had any high-risk HPV genotypes detected in the anus. Almost half (43.1%) had at least one quadrivalent HPV vaccine-preventable genotype (6, 11, 16 or 18) and one-fifth (21.0%) had HPV 16 detected in the anus. These findings suggest that a targeted catch-up HPV vaccination program for MSM is still beneficial to protect against high-risk HPV genotypes associated with anal cancer, as well as low-risk HPV genotypes. |
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| Keywords: | Vaccine HPV Gay men Vaccination MSM Catch-up program Human papillomavirus Homosexual Anal Cancer Prevention |
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