330例慢性光化性皮炎患者紫外线最小红斑量测定

目的:分析慢性光化性皮炎(CAD)患者与长波紫外线(UVA)、中波紫外线(UVB)的关系,以及最小红斑量(MED)的影响因素.方法:以SUV1000型日光紫外线模拟器作为照射光源,比较330例CAD患者不同性别、年龄、病程及不同季节受试者UVA-MED值及UVB-MED值.结果:男性患者UVB-MED值明显低于女性ME...

Determination of minimal erythema doses for ultraviolet radiation in 330 patients with chronic actinic dermatitis

Objective：To explore the minimal erythema dose for UVA and UVB radiation in patients with chronic actinic dermatitis (CAD).Methods：SUV1000 type UV simulator was used to measure the minimal erythema dose (MED) value of UVA and UVB radiation in 330 CAD patients with different sex, age, length of course, and season.Results：Compared with female patients ［(48.50±22.59) mJ/cm2］, male patients ［(45.23±21.01) mJ/cm2］ had significantly lower MED value of UVB (t=2.79, P=0.43). Compared with patients >50 years old, patients with 19 to 29 years old and 30 to 50 years old had much higher MED value for UVA and UVB (t=3.12, 1.03, 3.03, 1.32, respectively, all P<0.05). For the same gender, patients with a shorter course of fewer than 12 months had higher MED value for UVA and UVB than patients with a longer course（t=2.25, 2.81, 2.60, 2.34, respectively, all P<0.05）. The UVA-MED value of male CAD patients in summer was lower than those in spring and autumn (t=5.46, 3.21, respectively, both P<0.05), while there was no significant difference when compared with the value in winter (t=3.67, P=0.58). The UVB-MED value was significantly lower in the summer than the values in other seasons for both male and female patients (all P<0.05）.Conclusion：UVA and UVB play an important role in the pathogenesis of CAD. Sex, age, course of the disease, and seasonal variation are important factors of UVA-and UVB-MED in patients with CAD.