围绝经期合并乳腺良性增生性疾病患者全程化药学服务模式构建与实践

目的:建立围绝经期合并乳腺良性增生性疾病患者的全程化药学服务模式,并评价激素补充治疗(hormone replace-ment therapy,HRT)用于这类特殊患者的有效性和安全性.方法:介绍某院更年期联合门诊服务于围绝经期合并乳腺良性增生性疾病患者的工作模式、团队构建和药师职责.统计分析142例乳腺良性增生性疾病...

Establishment and practice of integrated pharmaceutical care mode in perimenopausal women with breast benign proliferative disease

OBJECTIVE To establish the integrated pharmaceutical care mode in perimenopausal women with breast benign proliferative disease and evaluate the efficacy and safety of hormone replacement therapy (HRT) in these special patients.METHODS The service mode, team-building, pharmacist duties of Menopause Physician-Pharmacist Joint Outpatient Clinic for perimenopausal women with breast benign proliferative disease were introduced.General profiles disease status, combined medications, pharmaceutical care content, outcome of perimenopausal symptoms and development of benign proliferative breast diseases were statistically analyzed.RESULTS Among 142 patients, 77.46% had concomitant medications.Under the integrated pharmaceutical care, 80.56% with one type of benign breast disease (n=108) and 70% with two or more types of benign breast disease (n=20) received HRT.The modified Kupperman symptom score (K-score) was significantly lower than that before treatment after three months.As compared with non-HRT treatment group, estrogen and estrogen-progestin treatment groups had a more significant decline in K-score and the difference was statistically significant (P<0.05), hinting that the treatment efficacy was marked.Fourteen patients with previous negative breast color ultrasound developed new benign breast diseases during treatment.Eight of them discontinued HRT and switched to other medications.No case of malignant breast lesions occurred during monitoring.CONCLUSION Clinical pharmacists may participate in joint outpatient clinics to implement full-course drug treatment management for special patients.It can improve the level of rational drug use, drug treatment safety, treatment outcomes and patient compliance.