Statin use and medically attended acute respiratory illness among influenza vaccine recipients |
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| Affiliation: | 1. Medicine Services, VA North Texas Health Care System, Dallas, TX, United States;2. Department of Internal Medicine, Division of Infectious Diseases and Geographic Medicine, University of Texas Southwestern Medical Center, Dallas, TX, United States;3. Department of Pharmacy Practice, Texas Tech University Health Sciences Center, School of Pharmacy, 5920 Forest Park, Dallas, TX, United States;4. Department of Population and Data Sciences, University of Texas Southwestern Medical Center, Dallas, TX, United States;5. Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, United States;1. Department of Health Crisis Management, National Institute of Public Health, 2-3-6 Minami, Wako-shi, Saitama 351-0197, Japan;2. Division of Environmental Medicine, National Defense Medical College, 3-2 Namiki, Tokorozawa-shi, Saitama 359-8513, Japan;3. Health Care Center, Japan Self-Defense Forces Central Hospital, 1-2-24 Ikeziri, Setagaya-ku, Tokyo 154-8532, Japan;4. Antigen Discovery, Inc., Irvine, CA, United States;5. Department of Veterinary Science, National Institute of Infectious Diseases, Toyama 1-23-1, Shinjuku-ku, Tokyo 162-8640, Japan;6. Department of Virology I, National Institute of Infectious Diseases, Toyama 1-23-1, Shinjuku-ku, Tokyo 162-8640, Japan;7. KM Biologics Co., Ltd, Kyokushi, Kikuchi, Kumamoto 860-8568, Japan;1. Department of Hematology, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany;2. Rheinisch-Westfälisches Institut für Wirtschaftsforschung, Essen, Germany;3. Department of Bone Marrow Transplantation, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany;4. Department of Internal Medicine III, University of Ulm, Ulm, Germany;5. Department of Hematology, Oncology, Infectious Diseases and Palliative Care, Alb-Fils-Kliniken, Göppingen, Germany;6. Reference Centre for Meningococci and Haemophilus Influenzae, Institute for Hygiene and Microbiology, University of Würzburg, Würzburg, Germany;1. Center for Health Research, Kaiser Permanente Northwest, Portland, OR, United States;2. HealthPartners Institute, Minneapolis, MN, United States;3. Institute for Health Research, Kaiser Permanente Colorado, Aurora, CO, United States;4. Marshfield Clinic Research Institute, Marshfield, WI, United States;5. Research and Evaluation, Kaiser Permanente Southern California, Pasadena, CA, United States;6. Kaiser Permanente Washington Health Research Institute, Seattle, WA, United States;7. Kaiser Permanente Vaccine Study Center, Kaiser Permanente Northern California, Oakland, CA, United States;8. Immunization Safety Office, Centers for Disease Control and Prevention, Atlanta, GA, United States;1. University of Waterloo, School of Public Health and Health Systems, Canada;2. University of Waterloo, Department of Psychology, Canada;1. Battelle Biomedical Research Center, 1425 Plain City Georgesville Road, JM7, West Jefferson, OH 46162, USA;2. Emergent BioSolutions Inc., 300 Professional Drive, Gaithersburg, MD 20879, USA |
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| Abstract: | BackgroundPrevious studies have suggested that statins decrease influenza vaccine effectiveness and increase risk of medically attended acute respiratory illness (MAARI).ObjectivesTo examine the association of incident statin use and MAARI in a cohort of influenza vaccine recipients.MethodsThis retrospective cohort study evaluated influenza vaccine recipients within the Tricare population. The primary outcome compared MAARI incidence during the follow-up period in a propensity score-matched cohort of incident statin users and statin non-users. Secondary analysis included propensity score-adjusted comparisons between incident statin users and statin non-users in the entire cohort and prespecified sub-cohorts with and without comorbidities. The propensity score was derived from 72 variables encompassing demographics, medical history, comorbidities, medication use, and healthcare utilization.ResultsMAARI incidence in statin users was similar to non-users in the propensity score-matched cohort (odds ratio [OR] 0.92; 95% confidence interval [CI] 0.84–1.01). In contrast, statin users with lower comorbidity had lower OR for MAARI compared to non-users (Charlson Score zero cohort: 0.85 [CI 0.74–0.98]; No Diabetes cohort: 0.88 [CI 0.80–0.96]).ConclusionIncident statin use was not associated with increased MAARI incidence and may be associated with lower incidence of MAARI in those with less comorbidity. This study thus offers reassurance regarding the effectiveness of the influenza vaccine in statin users. |
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