臭氧自血疗法联合药物治疗带状疱疹后神经痛的疗效评价

 目的探讨臭氧自血疗法联合药物治疗带状疱疹后神经痛（PHN）的效果。方法纳入118例PHN患者并随机分为对照组和观察组，每组59例。对照组采用双氯芬酸、普瑞巴林和甲钴胺药物口服治疗，观察组在此基础上联合臭氧自血疗法，均治疗1个月。使用VAS评分、SF-MPQ评分及WHOQOL-BREF量表评估治疗前、治疗后1周、2周和1个月时所有PHN患者的症状改善情况，同时检测血浆β-内啡肽、P物质、IL-1β和TNF-α的水平。结果完成研究103例，其中对照组52例，治疗组51例。与对照组相比，观察组患者治疗后1个月时VAS评分(t=2.38）、SF MPQ评分(t=2.72)和WHOQOL BREF评分(t=2.54)均有统计学差异(均P<0.05)，观察组血浆β-内啡肽水平(t=2.61)明显提高，P物质水平(t=2.48)、IL-1β(t=2.32)和TNF-α(t=2.40)水平明显下降(均P<0.05)。结论臭氧自血疗法联合药物治疗优于单纯药物治疗PHN。

Effect of the combination of ozone autohemotherapy and drugs for postherpetic neuralgia

ObjectiveTo investigate the effect and safety of ozone autohemotherapy combined with drugs in the treatment of postherpetic neuralgia (PHN). MethodsA total of 118 patients with PHN were randomly divided into the control group and the observational group (59 patients/group). PHN patients in the control group were treated with diclofenac, pregabalin and mecobalamin for one month,while patients in the observational group was given ozone autohemotherapy and drug treatment for 1 month. Visual analogue scale (VAS), SF-McGill pain questionnaire (SF-MPQ) and WHOQOL-BREF scale were used to evaluate the conditions of all PHN patients before the treatment and 1 week, 2 weeks and 1 month after treatment. The radioimmunoassay was used to detect the levels of plasma β endorphin and substance P, and ELISA was used to detect the levels of plasma IL-1β and TNF-α. ResultsTotal 52 patients in the control group and 51 patients in the observational group completed the study. Compared to baseline, VAS, SF-MPQ and WHOQOL-BREF scores were significantly improved in both groups at 1 week, 2 weeks and 1 month. In addition, the scores of VAS, SF-MPQ and WHOQOL-BREF of patients in the observational group were significantly improved when comparied with patients in the controls at 2 weeks and 1 month. Compared with patients in the control group, the levels of plasma β-endorphin were significantly increased, while the levels of substance P, IL-1β and TNF-α were significantly decreased in patients in the observational group. ConclusionThe effect of ozone autohemotherapy combined with drug therapy is superior to drug therapy alone for PHN.