经口内镜下贲门缩窄术治疗反流性食管炎效果的Meta分析

目的系统评价经口内镜下贲门缩窄术（PECC）对反流性食管炎（RE）的治疗效果。 方法计算机检索中国知网、维普网、万方数据知识服务平台、中国生物医学、the Cochrane Library、OVID、PubMed、EMBase数据库从2013年1月1日至2022年3月10日有关PECC治疗RE的随机对照试验。对符合纳入标准的文献进行资料提取和质量评价，使用RevMan 5.4软件对数据进行Meta分析。 结果共纳入5篇文献，共352例患者。Meta分析结果显示，PECC组治疗RE有效率高于质子泵抑制剂对照组（OR=5.55，95%CI：1.90~16.22），复发率低于对照组（OR=0.11，95%CI：0.04~0.35）。 结论PECC对RE患者具有较好的临床治疗效果，但本Meta分析纳入的文献及研究数量较少，以后仍需收集更多相关研究进行验证。

Meta analysis of therapeutic effect of peroral endoscopic cardial constriction on reflux esophagitis

ObjectiveTo systematically evaluate the therapeutic effect of peroral endoscopic cardial constriction (PECC) on reflux esophagitis (RE). MethodsWe searched the randomized controlled trial (RCT) studies of PECC in the treatment of RE from January 1, 2013 to March 10, 2022 in databases of CNKI, VIP, Wanfang Data knowledge service platform, China biomedicine, the Cochrane Library, Ovid, PubMed and EMBASE by computer. Data extraction and quality evaluation were conducted for the literatures that met the inclusion criteria. We used Revman 5.4 software to perform meta-analysis on the data. ResultsThis meta-analysis included in 5 articles and a total of 352 patients. Results of meta-analysis showed that the effective rate of RE in PECC group was higher than that in proton pump inhibitor (PPI) control group (OR=5.55,95%CI:1.90-16.22), and the recurrence rate was lower than that in control group (OR=0.11,95%CI:0.04-0.35). ConclusionPECC has a good clinical therapeutic effect on RE. The literatures and studies included in this meta-analysis are few, so we need to collect more relevant studies for verification in the future.