| 表没食子儿茶素没食子酸酯研究进展 |
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| 作者姓名： | 曾露 张帅 艾静 |
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| 作者单位： | 哈尔滨医科大学药学院药理教研室，哈尔滨，150086，中国 |
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| 基金项目： | 国家自然科学基金资助项目（No.81870849，No.81671052），黑龙江省自然基金重点项目（No.ZD2018004） |
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| 摘 要： | 表没食子儿茶素没食子酸酯（epigallocatechin gallate，EGCG）是从茶叶中分离得到的儿茶素类单体，是茶叶茶多酚的主要组成成分。它具有抗氧化、抗炎、抗肿瘤、抗代谢性疾病、心血管和神经保护作用等多种生物活性。近年来，越来越多关于EGCG的体内活性和药用价值的研究表明，EGCG可能具有重要的临床应用价值。因此本文就EGCG的药动学、药理学及毒理学研究进展进行了综述，以期为EGCG的进一步开发和利用提供理论依据。
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| 关 键 词： | EGCG 药代动力学 药效动力学 急性毒性 慢性毒性 |
Research Progress of Epigallocatechin Gallate |
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| Authors: | ZENG Lu ZHANG Shuai AI Jing |
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| Institution: | Department of Pharmacology，College of Pharmacy of Harbin Medical University ，Harbin，150086，China |
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| Abstract: | Epigallocatechin gallate
(EGCG) , the main component of tea polyphenols, is a catechin monomer isolated
from tea. It has a variety of biological activities such as antioxidation,
anti-inflammation, anti-tumor, anti-metabolic diseases, cardiovascular and neuronal protective effects. In recent years, more and
more studies related to the in vivo activity and medicinal values of EGCG have revealed that it may have important
clinical application values. Therefore, this
paper reviewed the advances in pharmacokinetics，pharmacology and toxicology of EGCG, so as to provide
theoretical basis for the further development and utilization of EGCG. |
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| Keywords: | EGCG pharmacokinetics pharmacodynamics acute toxicity chronic toxicity |
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