| 肠道菌群和胃食管反流病发病的相关性 |
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| 作者姓名： | 崔剑昱 艾克拜尔· 艾力 克力木· 阿不都热依木 玉素江· 图荪托合提 |
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| 作者单位： | 1. 乌鲁木齐 8300054，新疆医科大学研究生学院2. 乌鲁木齐 830001，新疆维吾尔自治区人民医院微创、疝和腹壁外科；乌鲁木齐 830001，新疆维吾尔自治区人民医院普外微创研究所 |
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| 基金项目： | 国家自然科学基金项目(82060166); 上海合作组织科技伙伴计划及国际科技合作计划(2020E01014) |
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| 摘 要： | 胃食管反流病（GRED）是一种较为常见的消化道疾病，其发病机理复杂，受多种因素的影响。近几年的研究表明，GERD与肠道菌群之间存在某种相关性。GERD可能与肠道菌群的紊乱引起机体炎症介质、5-羟色胺及脑－肠轴变化有关。本文就GERD与肠道微生物的关系进行了综述。
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| 关 键 词： | 胃食管反流病 肠道菌群 炎症介质 5-羟色胺 脑－肠轴 |
| 收稿时间： | 2021-05-19 |
The Correlation study of the incidence of intestinal flora and gastroesophageal reflux disease |
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| Authors: | Jianyu Cui Aikebaier· Ai Kelimu· Abudureyim Yusujiang· Tusuntuoheti |
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| Institution: | 1. Xinjiang Medical University Graduate School of Medicine, Urumqi 830054,China2. Department of Minimally Invasive Surgery,Hernia and Abdominal Wall Surgery ,Urumqi 830001,China; Research Institute of General and Minimally Invasive Surgery, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001 |
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| Abstract: | Gastroesophageal reflux disease (GRED) is a relatively common gastrointestinal disease with a complex pathogenesis and is influenced by a variety of factors. The results showed that there was some correlation between GERD and the gut microbiome. GERD may be due to inflammatory mediators, 5-hydroxytriptamin, immunity, brain-gut axis, and other factors. This article reviews the relationship between GERD and the gut microbiome. |
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| Keywords: | Gastroesophageal reflux disease Intestinal flora Mediator of inflammation 5-hydroxytriptamin Brain-gut axis |
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