| miRNA-29b参与上皮间质转化相关信号通路调控的研究进展 |
| |
| 引用本文： | 王俊鑫,孙岩. miRNA-29b参与上皮间质转化相关信号通路调控的研究进展[J]. 山东大学耳鼻喉眼学报, 2021, 35(6): 132-137. DOI: 10.6040/j.issn.1673-3770.0.2021.096 |
| |
| 作者姓名： | 王俊鑫 孙岩 |
| |
| 作者单位： | 潍坊医学院临床医学院,山东潍坊261053;青岛大学附属烟台毓璜顶医院耳鼻咽喉头颈外科/山东省耳鼻喉疾病临床医学研究中心,山东烟台264000 |
| |
| 基金项目： | 烟台市科技创新发展计划(2021MSGY046);山东省自然科学基金项目(ZR2021MH378) |
| |
| 摘 要： | 上皮间质转化(EMT)是上皮细胞转化为间质细胞的生物学过程,它赋予细胞转移和入侵的能力,与器官纤维化和肿瘤发生发展密切相关。miRNA-29b是一类与EMT过程密切相关的非编码小RNA,直接或间接调控TGF-β/Smad、PI3K/AKT、Wnt/β-catenin等多条信号通路,参与Ⅱ型和Ⅲ型EMT的发展过程,进而延缓器官纤维化进程,调控肿瘤的侵袭转移。针对miRNA-29b的靶向治疗,有望为临床诊断、治疗器官纤维化和肿瘤侵袭转移提供新视角。本文就miRNA-29b通过多条EMT相关信号通路调控器官纤维化和肿瘤侵袭转移过程的研究现状进行综述。
|
| 关 键 词： | miRNA-29b 上皮间质转化 器官纤维化 肿瘤侵袭转移 信号通路 |
Research progress of miRNA-29b involved in EMT-related signaling pathway regulation |
| |
| WANG Junxin,SUN Yan. Research progress of miRNA-29b involved in EMT-related signaling pathway regulation[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2021, 35(6): 132-137. DOI: 10.6040/j.issn.1673-3770.0.2021.096 |
| |
| Authors: | WANG Junxin SUN Yan |
| |
| Affiliation: | 1. College of Clinical Medicine, Weifang Medical University, Weifang 261053, Shandong, China;2. Department of Otorhinolaryngology & Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University / Shandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases, Yantai 264000, Shandong, China |
| |
| Abstract: | Epithelial-mesenchymal transition(EMT)is a biological process of epithelial cells transforming into mesenchymal cells, conferring the ability of cell metastasis and invasion. This process is closely related to the progression of organ fibrosis and tumors. MiRNA-29b is a small noncoding RNA closely related to the EMT process. By modulating TGF-β/Smad, PI3K/AKT, Wnt/β-catenin, and other signaling pathways, miRNA-29b mediates the development of type II and type III EMT, and then delays the process of organ fibrosis, regulates the invasion and metastasis of tumors. The targeted therapy of miRNA-29b is expected to provide a new perspective for the clinical diagnosis and treatment of organ fibrosis and tumor invasion and metastasis. The research status of miRNA-29b regulating the process of organ fibrosis and tumor invasion and metastasis through various EMT-related signaling pathways was reviewed in this study. |
| |
| Keywords: | MiRNA-29b Epithelial-mesenchymal transition Organ fibrosis Tumor invasion and metastasis Signaling pathway |
| 本文献已被 万方数据 等数据库收录！ |
| 点击此处可从《山东大学耳鼻喉眼学报》浏览原始摘要信息 |
|
点击此处可从《山东大学耳鼻喉眼学报》下载全文 |
|
