High rate of rubella seronegativity in perinatally-infected HIV women of childbearing age: A case-control study |
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| Affiliation: | 1. Department of Infectious Diseases, Centre Hospitalier Universitaire Saint-Pierre, Université Libre de Bruxelles (ULB), Brussels, Belgium;2. Epidemiology of Infectious Diseases, Sciensano, Brussels, Belgium;3. Department of Paediatrics, Centre Hospitalier Universitaire Saint-Pierre, Université Libre de Bruxelles (ULB), Brussels, Belgium;4. Department of Obstetrics-Gynecology, Centre Hospitalier Universitaire Saint-Pierre, Université Libre de Bruxelles (ULB), Brussels, Belgium;5. Microbiology, Laboratoire Hospitalier Universitaire de Bruxelles-Universitair Laboratorium Brussel (LHUB-ULB), Brussels, Belgium;6. Centre for Environmental Health and Occupational Health, School of Public Health, Université libre de Bruxelles (ULB), Belgium;7. Institute for Medical Immunology, Université libre de Bruxelles (ULB), Belgium;1. Yale School of Public Health, Department of Epidemiology of Microbial Diseases, 60 College Street, New Haven, CT 06520, USA;2. Yale School of Medicine, Department of Pediatrics, PO Box 208064, New Haven, CT 06520, USA;1. Duke University School of Medicine, Durham, NC, USA;2. Division of Practice Advancement and Clinical Education, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA;3. Department of Health Policy Planning and Management, Makerere University School of Public Health, Makerere University, Kampala, Uganda;4. Department of Maternal and Child Health, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA;1. Department of Obstetrics and Gynecology, Hôpital Foch, 92120 Suresnes, France;2. Risk in Pregnancy University Department, IAME, INSERM, Université Paris-Diderot, 75013 Paris, France;3. Groupe de Recherche sur les Infections pendant la Grossesse (GRIG), France;4. AP-HP, Hôpital Paul Brousse, Department of Virology, WHO Rubella NRL, 94804 Villejuif, France;5. AP-HP, Hôpital Antoine Béclère, Department of Obstetrics, Gynecology and Reproductive Medicine, Univ Paris-Sud, 92140 Clamart, France;6. EA2493, Université Versailles Saint-Quentin-en-Yvelines, 78180 Montigny-le-Bretonneux, France;7. Hôpital Foch, DRCI-Clinical Research Unit, 92120 Suresnes, France;8. Univ Paris-Sud, INSERM U1193, Villejuif, 94804 France |
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| Abstract: | Rubella infection is a vaccine preventable disease. Maternal infection during pregnancy may lead to congenital infection and severe foetal malformations. Thanks to antiretroviral therapy, perinatally HIV-infected women have better prognosis and are now experiencing pregnancy. We evaluated the rate of rubella seronegativity in a cohort of HIV perinatally-infected women of childbearing age. A high rate of seronegativity was found in this group as compared to age-matched non-perinatally infected HIV-infected women (34.5% vs 6.90%, p < 0.01). MMR administration before rubella testing was identified in 75.8% of perinatally-infected women (22/29) with a mean of 2 doses (range: 1–3 doses). HIV perinatally-infected women of childbearing age should be screened repeatedly for rubella immunity. |
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| Keywords: | Rubella vaccine Vertical transmission Seroprevalence Vaccine HIV |
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