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Validation of parental reports of rotavirus vaccination of their children compared to the national immunization registry |
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| Institution: | 1. Department of Epidemiology and Preventive Medicine, School of Public Health, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Tel Aviv, Israel;2. Division of Epidemiology, Ministry of Health, Jerusalem, Israel;3. Department of Pediatrics, Hillel Yaffe Medical Center, Hadera, Israel;4. Department of Pediatrics, Laniado Medical Center, Netanya, Israel;5. Department of Pediatrics, Carmel Medical Center, Haifa, Israel;6. Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel;1. University of Pittsburgh School of Medicine, Pittsburgh, Pa;2. Department of Surgery Mount Sinai Medical Center, New York, NY;3. Houston-Methodist-Debakey Heart and Vascular Center, Houston, Tex;4. Beth Israel Deaconess Medical Center, Boston, Mass;5. Johns Hopkins University School of Medicine, Baltimore, Md;6. University of Michigan, Ann Arbor, Mich;7. Duke University Medical Center, Durham, NC;8. Medtronic, Inc, Minneapolis, Minn;1. Johns Hopkins Berman Institute of Bioethics, Johns Hopkins University, USA;2. Department of International Health, Johns Hopkins University Bloomberg School of Public Health, USA;3. Johns Hopkins Center for Immunization Research, Johns Hopkins School of Public Health, USA;4. Institute for Vaccine Safety, Johns Hopkins University Bloomberg School of Public Health, USA;5. Department of Health, Behavior & Society, Johns Hopkins University Bloomberg School of Public Health, USA;6. Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, USA;1. Department of Internal and Pulmonary Medicine, Sheri Kashmir Institute of Medical Sciences, Soura, Srinagar 190011, Jammu and Kashmir, India;2. Postgraduate Department of Microbiology, Government Medical College, Srinagar, Jammu and Kashmir, India;3. Juhur-ul-Islam Medical College, Bajitpur, Bangladesh |
| Abstract: | BackgroundThe introduction of rotavirus vaccines into national immunization programs necessitates vaccine effectiveness evaluations. Parental report of vaccination status is a simple and accessible source of information; however, its validity is unclear.AimsTo validate parental reports of rotavirus immunization compared to documentation of vaccination in national immunization registry, and to assess vaccine effectiveness by each method.MethodsParents of 1272 children aged 2–59 months from northern Israel hospitalized for gastroenteritis in 2011–2015 were interviewed on the sociodemographics and rotavirus vaccination status of their child. Rotavirus immunization status based on parental report was compared to that documented in the national immunization registry, which was considered the gold standard. Stool samples collected from patients were tested for rotavirus antigen by immunochromotgraphy. In a rotavirus test-negative case-control study, vaccination history was compared between children found positive for rotavirus and those who tested negative. Vaccine effectiveness for ≥ 1 dose vs. zero doses was calculated as: (1-adjusted odds ratio) * 100.ResultsThe sensitivity and specificity of parental report of their child's immunization with a rotavirus vaccine were 97% (95% CI 96–98), and 75% (95% CI 65–82), respectively. Kappa coefficient was 0.69 (p < 0.001) for the agreement between the two methods. Rotavirus vaccine effectiveness was 72% (95% CI 54–84) when using parental report of rotavirus immunization and 79% (95% CI 62–88) when using the registry.ConclusionParental report of their child's immunization with a rotavirus vaccine demonstrated high sensitivity, although the specificity was relatively low. Vaccine effectiveness was similar regardless of method used to determine rotavirus immunization status. Parental report of vaccination status can be useful in vaccine effectiveness assessment. |
| Keywords: | Validity Parental report Registry Rotavirus immunization Effectiveness bOPV"} {"#name":"keyword" "$":{"id":"k0035"} "$$":[{"#name":"text" "_":"bivalent oral polio vaccine CI"} {"#name":"keyword" "$":{"id":"k0045"} "$$":[{"#name":"text" "_":"confidence intervals DTP"} {"#name":"keyword" "$":{"id":"k0055"} "$$":[{"#name":"text" "_":"diphtheria tetanus pertussis MMR"} {"#name":"keyword" "$":{"id":"k0065"} "$$":[{"#name":"text" "_":"measles mumps rubella OR"} {"#name":"keyword" "$":{"id":"k0075"} "$$":[{"#name":"text" "_":"odds ratio RVGE"} {"#name":"keyword" "$":{"id":"k0085"} "$$":[{"#name":"text" "_":"rotavirus gastroenteritis SD"} {"#name":"keyword" "$":{"id":"k0095"} "$$":[{"#name":"text" "_":"standard deviation SES"} {"#name":"keyword" "$":{"id":"k0105"} "$$":[{"#name":"text" "_":"socioeconomic status |
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