利那洛肽胶囊联合低剂量聚乙二醇电解质散用于结肠镜肠道准备的可行性与安全性

目的探讨利那洛肽胶囊联合低剂量复方聚乙二醇电解质散(PEG)作为肠镜检查前肠道清洁剂的可行性与安全性。 方法选取2022年3月至2022年5月经保定市第一中心医院门诊拟行肠镜检查的300例受试者作为研究对象。采用随机数字表，将受试者随机分为三组，每组各100例患者。A组作为对照组单用3盒PEG、B组利那洛肽胶囊2粒(290 μg/每粒)联合2盒PEG清肠、C组3粒利那洛肽胶囊联合2盒PEG清肠，比较三组患者肠道清洁程度及不良事件的发生率。 结果B组左半结肠、横结肠、右半结肠及总Boston肠道准备量表(BBPS)均与A组差异无统计学意义(P>0.05)；C组左半结肠、横结肠、右半结肠及总BBPS均高于A组，具有统计学意义(P<0.05)，B组的左半结肠、横结肠、右半结肠及总BBSP评分均低于A组，具有统计学意义(P<0.05)。不良事件发生率方面，B、C组均低于A组，差异有统计学意义(P<0.05)。B、C组之间差异无统计学意义(P>0.05)。 结论利那洛肽胶囊2粒联合2盒PEG肠道清洁度与单用3盒PEG相似，利那洛肽胶囊3粒联合2盒PEG清肠效果优于单用3盒PEG。2种联合用药方式不良事件发生率均低于单用3盒PEG。

Feasibility and safety of linaclotide combined with low dose polyethylene glycol as intestinal cleanser

ObjectiveTo investigate the feasibility and safety of linaclotide capsule combined with low-dose compound polyethylene glycol electrolyte powder (PEG) as intestinal detergent before colonoscopy. MethodsA total of 300 subjects who planned to undergo colonoscopy in the outpatient department of Baoding First Central Hospital from March 2022 to May 2022 were selected as the research objects. The subjects were randomly divided into three groups with 100 patients in each group by random number table. Group A was treated with 3 boxes of PEG alone, group B with 2 boxes of linaclotide capsules (290 μg/capsules) combined with 2 boxes of PEG intestinal cleanse, and group C with 3 boxes of linaclotide capsules combined with 2 boxes of PEG intestinal cleanse. The degree of intestinal cleanliness and the incidence of adverse events were compared among the three groups. ResultsThere were no significant differences in left colon, transverse colon, right colon and total Boston bowel Preparation Scale (BBPS) between group B and group A (P> 0.05). The left colon, transverse colon, right colon and total BBPS of group C were higher than those of group A, with statistical significance (P< 0.05). The left colon, transverse colon, right colon and total BBSP scores of group B were lower than those of group A, with statistical significance (P< 0.05). The incidence of adverse events in groups B and C was lower than that in group A, and the difference was statistically significant (P< 0.05). There was no significant difference between groups B and C (P> 0.05). ConclusionThe intestinal cleanliness of 2 linaclotide capsules combined with 2 boxes of PEG is similar to that of 3 boxes of PEG alone. The intestinal cleansing effect of 3 linaclotide capsules combined with 2 boxes of PEG is better than that of 3 boxes of PEG alone. The incidence of adverse events was lower in the two drug combinations than in the three-box PEG alone.