The advances in brucellosis vaccines |
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| Affiliation: | 1. Key Laboratory of Zoonosis, Ministry of Education, Institute of Zoonosis, Jilin University, Changchun 130062, China;2. Tumor Hospital of Jilin Province, Changchun 130021, China;1. Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences (CAAS), Shanghai, 200241, China;2. Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonosis, Yangzhou, China;1. Division of Bacteriology & Mycology, Indian Veterinary Research Institute, Izatnagar, India;2. Immunology Section, Indian Veterinary Research Institute, Izatnagar, India;1. Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences (CAAS), Shanghai, 200241, China;2. College of Animal Science and Technology, Shandong Agricultural University, Taian, 271018, China;1. Key Laboratory of Animal Epidemiology and Zoonosis of Ministry of Agriculture, State Key Laboratory for Agrobiotechnolgy, National Animal Protozoa Laboratory & College of Veterinary Medicine, China Agricultural University, Beijing, China;2. China Institute of Veterinary Drug Control, Beijing, China;3. College of Animal Science and Veterinary Medicine, Shandong Agricultural University, Taian, Shandong, China;1. Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences (CAAS), Shanghai, 200241, China;2. College of Animal Science and Technology, Shandong Agricultural University, Taian, 271018, China |
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| Abstract: | Brucellosis is a worldwide zoonosis affecting animal and human health. Till now, there is no effective vaccine licensed for brucellosis in humans. Although M5, H38 and 45/20 vaccines were used to prevent animal brucellosis in the early stages, the currently used animal vaccines are S19, Rev.1, S2, RB51 and SR82. However, these vaccines still have several drawbacks such as residual virulence and interfering conventional serological tests. With the development of DNA recombination technologies and the completion of the sequence of Brucella genome, much research focuses on the search for potential safer and more effective vaccines. Preliminary studies have demonstrated that new vaccines, including genetically engineered attenuated vaccines, subunit vaccines and other potential vaccines, have higher levels of protection, but there are still some problems. In this paper, we briefly review the main vaccines that have been used in controlling the brucellosis for decades and the progress in the development of new brucellosis vaccines. |
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| Keywords: | Brucellosis Vaccine |
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