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Comparison of a frailty short interview to a validated frailty index in adults hospitalized for acute respiratory illness |
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| Institution: | 1. Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, United States;2. Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, United States;3. Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States;4. Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA, United States;5. Department of Medicine, University of Tennessee Health Science Center, Saint Thomas Health, Nashville, TN, United States;6. Department of Health Policy, Vanderbilt University Medical Center, Nashville, TN, United States;1. Department of Internal Medicine, University Hospitals Cleveland Medical Center, Case Western Reserve University, 11100, Euclid Avenue, Cleveland, OH, 44106, USA;2. Department of Radiology, University Hospitals Cleveland Medical Center, Cleveland, OH, 44106, USA;3. Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, 44106, USA;4. School of Medicine, Case Western Reserve University, Cleveland, OH, 44106, USA;5. Department of Gastroenterology, University Hospitals Cleveland Medical Center, Cleveland, OH, 44106, USA;6. Department of Gastroenterology, Cleveland Clinic Foundation, Cleveland, OH, 44106, USA;1. Institute of Physics, Academy of Sciences of the Czech Republic, Cukrovarnická 10, 162 00 Prague 6, Czech Republic;2. Czech Metrology Institute, Okru?ní 31, 638 00 Brno, Czech Republic;3. HVM plasma s.r.o., Na Hutmance 2, Praha 5, Czech Republic;4. Helmholtz Zentrum Berlin, Hahn-Meitner-Platz 1, Berlin, Germany;5. Gifu University, 1-1 Yanagido, Gifu, 501–1193 Japan;6. Laboratoire de Physique des Interfaces et des Couches Minces, CNRS, Ecole Polytechnique, 91128 Palaiseau, France;1. Department of Biology, Lakehead University, Thunder Bay, ON, Canada;2. Northern Ontario School of Medicine, Thunder Bay, ON, Canada;1. Plant, Soil and Microbial Sciences Department, Michigan State University, Plant & Soil Sciences Building, 1066 Bogue Street, Room 584D, East Lansing, MI 48824, USA;2. USDA-ARS, Environmental Microbial and Food Safety Laboratory, 10300 Baltimore Avenue, Building 173, BARC-East, Beltsville, MD 20705, USA;3. USDA-ARS, Environmental Management and Byproduct Utilization Laboratory, BARC-East, Building 306, Beltsville, MD 20705, USA;4. USDA-ARS Hydrology and Remote Sensing Laboratory, Building 007, Room 104, BARC-West, Beltsville, MD 20705-2350, USA |
| Abstract: | BackgroundFrailty is an important physiologic factor in studies of influenza and influenza vaccines carried out in older adults and hospitalized populations. Unfortunately, comprehensive assessments of frailty requiring physical assessments and extensive medical record review are not often feasible in time- and resource-limited settings common to studies of influenza and influenza vaccines.MethodsWe developed a 5-question frailty short interview, and implemented it in a multicenter, hospital-based study of influenza over two years. Frailty status defined by the frailty short interview was compared to a validated frailty index based on medical record review of 59 parameters. Agreement between the two frailty measures was assessed, and multivariable linear regression models were used to explore differences between the measures. The association between each frailty measure and likelihood of influenza vaccination was also assessed.ResultsDuring the 2015–2016 and 2016–2017 influenza seasons, 2070 adult patients hospitalized with acute respiratory illness were enrolled and included in analyses. Frailty was frequently identified in the study population; 43% of participants were defined as frail by the frailty short interview and 32% by frailty index. Responses to the frailty short interview were only moderately correlated with the frailty index, and agreement between the two frailty measures was low. Women were more likely to be defined as frail by the frailty short interview than men. White individuals were more likely than other races to be defined as frail by the frailty index. Increasing frailty index was associated with increased likelihood of influenza vaccination, but the frailty short interview was not associated with vaccination.ConclusionsThe frailty short interview provided a feasible and consistent measure of frailty across study hospitals and study years. However, its modest correlation with the frailty index and differential association with likelihood of influenza vaccination highlight differences in the conceptualization of frailty. |
| Keywords: | Influenza Influenza vaccination Frailty Hospitalization Adults CDC"} {"#name":"keyword" "$":{"id":"k0035"} "$$":[{"#name":"text" "_":"Centers for Disease Control and Prevention CI"} {"#name":"keyword" "$":{"id":"k0045"} "$$":[{"#name":"text" "_":"confidence interval HAIVEN"} {"#name":"keyword" "$":{"id":"k0055"} "$$":[{"#name":"text" "_":"Hospitalized Adult Influenza Vaccine Effectiveness Network IQR"} {"#name":"keyword" "$":{"id":"k0065"} "$$":[{"#name":"text" "_":"interquartile range US"} {"#name":"keyword" "$":{"id":"k0075"} "$$":[{"#name":"text" "_":"United States VE"} {"#name":"keyword" "$":{"id":"k0085"} "$$":[{"#name":"text" "_":"vaccine effectiveness |
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