痰热清注射液治疗急性呼吸系统感染及其并发症的快速卫生技术评估

目的:通过快速卫生技术评估,评价痰热清注射液用于急性呼吸系统感染及其并发症的有效性、安全性及经济性,为临床实践与决策者提供循证依据.方法:系统检索主要的中英文数据库,由2名评价者分别根据预设的纳入排除标准和数据提取表筛选文献和提取数据,并对结果进行综合分析.结果:共纳入13篇系统评价/Meta分析,以中等质量文献为主....

Tanreqing injection for acute respiratory infections and complications:a rapid health technology assessment

OBJECTIVE To provide evidences to healthcare providers and decision makers through a rapid health technology assessment of clinical effectiveness,safety and economy of Tanreqing Injection for acute respiratory infections and complications. METHODS Several major Chinese and English databases were systematically searched.After independent study selection,data extraction and quality assessment,included studies were comprehensively analyzed.RESULTS A total of 13 systematic reviews/Meta-analyses with fair average quality were included.As compared with antibiotics/antiviral agents/conventional therapy for pneumonia,bronchitis,systemic inflammatory response syndrome and H1N1 alone,combined treatment of Tanreqing Injection could improve the overall effective rate.And the difference was statistically significant(P<0.05).No significant difference existed in overall effective rate between Tanreqing Injection and antibiotics in the treatment of either pneumonia or bronchitis(P>0.05).However,fever clearance time and cough disappearance time benefited from Tanreqing Injection.And the difference was statistically significant(P<0.05).As compared with antibiotics alone,co-using Tanreqing Injection showed no increased risk of adverse drug reaction(P>0.05).As compared with levofloxacin alone for community-acquired pneumonia,Tanreqing Injection plus levofloxacin demonstrated a cost-effective advantage. CONCLUSION Tanreqing Injection plus antibiotics/antiviral agents/conventional therapy offer better effectiveness and economy for acute respiratory infections and complications while safety risk remains the same.Large samples and high-quality validation studies are still required.