体检人群甘油三酯葡萄糖指数对非酒精性脂肪性肝病发病风险的诊断价值

目的探讨体检人群甘油三酯葡萄糖(TyG)指数对非酒精性脂肪性肝病(NAFLD)发病风险的诊断价值。 方法选取2018年12月至2019年12月于克拉玛依市中西医结合医院(市人民医院)进行健康体检的新疆油田公司和西部钻探公司的8 860例企业职工作为研究对象。采集研究对象的一般临床资料、血液生化指标、超声检查结果等，并计算TyG指数。应用多因素Logistic回归，分析NAFLD的危险因素；并使用受试者工作特征(ROC)曲线分析TyG指数对NAFLD发病的预测价值。 结果3 261例为NAFLD。多因素Logistic回归分析结果显示，TyG指数、年龄、收缩压、腰围和丙氨酸转氨酶是NAFLD的独立危险因素，OR值(95%CI)分别为3.294(2.933~3.699)、1.013(1.006~1.020)、1.007(1.001~1.012)、1.092(1.085~1.100)和1.029(1.026~1.033)(均P<0.05)。ROC曲线分析结果显示，TyG指数的曲线下面积为0.818，TyG指数诊断NAFLD的截断值为4.310。 结论TyG指数能够较好预测NAFLD的发病风险，可作为筛查NAFLD高危人群的有效指标。

The diagnostic value of the triglyceride-glucose index in predicting the risk of non-alcoholic fatty liver disease in physical examination population

ObjectiveTo explore the predictive value of triglyceride-glucose (TyG) index on the risk of non-alcoholic fatty liver disease (NAFLD) in physical examination population. MethodsFrom December 2018 to December 2019, a total of 8 860 employees from Xinjiang Oilfield Company and Western Drilling Company who underwent physical examinations in the Karamay Integrated Chinese and Western Hospital (Municipal People′s Hospital) were chosen as the research subjects. The subjects′ general clinical data, blood biochemical indexes, and ultrasonic examination results were collected, and the TyG index was calculated. The risk factors for NAFLD were studied using multivariate logistic regression. The receiver operating characteristic (ROC) curve was used to assess the predictive value of the TyG index for NAFLD. ResultsNAFLD affected 3 261 patients. The TyG index, age, systolic blood pressure, abdominal girth, and alanine aminotransferase were found to be independent risk factors for NAFLD, with ORs of 3.294(2.933-3.699), 1.013(1.006-1.020), 1.007(1.001-1.012), 1.092(1.085-1.100), and 1.029(1.026-1.033)(all P<0.05). The area under the curve (AUC) of TyG index was 0.818 according to the ROC curve analysis, and the cut-off value of TyG index in diagnosing NAFLD was 4.310. ConclusionThe TyG index can better predict NAFLD risk and be used as an effective indicator for screening NAFLD high-risk populations.