| 针刺对大鼠全脑环化-磷酸腺苷含量的影响 |
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| 引用本文： | 蒋莹,王敬玲,汤健,韩济生.针刺对大鼠全脑环化-磷酸腺苷含量的影响[J].针刺研究,1980(2). |
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| 作者姓名： | 蒋莹 王敬玲 汤健 韩济生 |
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| 作者单位： | 北京医学院基础医学研究所针麻原理研究室生理组，北京医学院基础医学研究所针麻原理研究室生理组，北京医学院基础医学研究所针麻原理研究室生理组，北京医学院基础医学研究所针麻原理研究室生理组 南京药学院 |
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| 摘 要： | <正> 近年来,许多作者报告内源性鸦片样物质(Endogenons Opiate Like Substan-ces,OLS)可以抑制腺苷酸环化酸,使脑内环化-磷酸腺苷(cAMP)含量降低。设法提高脑内cAMP的水平,则可对抗吗啡的镇痛作用。现已证明,内源性鸦片样物质在针刺镇痛过程中具有重要作用。在针刺过程中,脑内鸦片样物质亦明显升高。我们实验室还发现,给大鼠脑室注射cAMP,
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THE INFLUENCE OF ACUPUNCTURE ON THE CONTENT OF CEREBRAL cAMP IN RATS |
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| Abstract: | Rats were given electroacupuncture for 30 minutes and decapitated for determination of cerebralcAMP. There was a significant reduction of cerebtal cAMP with the elevation of pain threshold afteracupuncture. The content of cerebral cAMP was also recovered when analgesia had been disappeared afterstopping acupuncture. Intraventricular injection of Naloxon, an opiate receptor antagonist, may comple-tely reversed the lowering of cerebral cAMP, but it failed to block acupuncture analgesia. It can be suggested from the above results that there was a complex mechanism in acupuncture anal-gesia besides its effect on the endogenous opiate like substances and cAMP. |
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