血液灌流、血液透析联合纳洛酮治疗多脏器功能衰竭的临床研究

目的：探讨血液灌流、血液透析联合纳洛酮治疗多脏器功能衰竭（MOF）的临床疗效,以进一步指导临床治疗。方法：将我院2006年1月～2009年10月收治的60例MOF患者随机分为对照组（常规治疗组）和治疗组（联合治疗组）,观察比较两组的用药量、用药次数和治愈率。结果：治疗组用药量、用药次数较对照组明显降低（P〈0.05）,但治疗组的治愈率明显高于对照组（P〈0.05）。结论：血液灌流、血液透析联合纳洛酮治疗不失为一种治疗MOF的有效方法,但应尽早进行。

Clinical research of hemoperfusion,hemodialysis combined with naloxone on the treatment of multiple organ failure

Objective：To evaluate the clinical effects of the hemoperfusion,hemodialysis combined naloxone on the treatment of multiple organ failure（MOF） in order to further guide clinical treatment.Methods：From January 2006 to October 2009,60 cases of（MOF） patients were randomly divided into control group（routine treatment）：anti-infectives,including antibiotics,rehydration and give corrective acid,to maintain water and electrolyte balance,nutritional support for treatment symptomatic treatment of the primary disease and the important organs support;the treatment group：based on the control group,the increase of hemorerfusion dialysis plus naloxone in 30 cases,to compare the dosage,medication frequency and cure rate between two groups.Results：The dosage,medication frequency and medication of the treatment group were significantly lower compared with control group（P〈0.05）,but the cure rate of the treatment group was significantly higher than that of control group（P〈0.05）.Conclusion：Hemoperfusion,hemodialysis combined with naloxone on the treatment of MOF is an effective method,but should be soon as possible.