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EFFECTS OF EXTRADURAL ANALGESIA AND VAGAL BLOCKADE ON THE METABOLIC AND ENDOCRINE RESPONSE TO UPPER ABDOMINAL SURGERY
Authors:TRAYNOR, C.   PATERSON, J. L.   WARD, I. D.   MORGAN, M.   HALL, G. M.
Affiliation:Department of Anaesthetics, Royal Postgraduate Medical School, Hammersmith Hospital Du Cane Road, London W120HS
Department of Chemical Pathology, Southmead Hospital Bristol
Abstract:The effect of thoracic extradural analgesia and vagal blockadeon the metabolic t -1 endocrine responses to cholecystectomywas investigated. In comparison with a control grjf patients,extradural analgesia and vagal blockade abolished the glycaemicresponse to surgr jut had no effect on the increase in plasmacortisol. Circulating insulin values were significantly decreasedm the extradural group of patients, confirming the importanceof autonomic innervatir in maintaining basal insulin output.There is, at present, no satisfactory local analgesic techniquefor controlling the endocrine response to upper abdominal surgery.
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