| 肾间质纤维化动物模型的制作和研究进展 |
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| 引用本文： | 徐志宏,谌贻璞. 肾间质纤维化动物模型的制作和研究进展[J]. 基础医学与临床, 2006, 26(11): 1281-1285 |
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| 作者姓名： | 徐志宏 谌贻璞 |
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| 作者单位： | 中国协和医科大学,研究生院,北京,100730;卫生部,中日友好医院肾病中心,北京,100029 |
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| 摘 要： | 肾间质纤维化与肾功能的恶化密切相关。动物模型实验是研究肾间质纤维化必不可少的手段,实验者应根据不同的实验目的选择适当的动物模型。本文对常见的肾间质纤维化动物模型,包括单侧输尿管梗阻、环孢素A肾病、慢性马兜铃酸肾病等8种模型的制作和研究进展作一综述。
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| 关 键 词： | 肾问质纤维化 动物模型 |
| 文章编号： | 1001-6325(2006)11-1281-05 |
| 收稿时间： | 2006-05-25 |
| 修稿时间： | 2006-09-25 |
Recent advances of animal models of renal interstitial fibrosis |
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| X Zhi-hong,CHEN Yi-pu. Recent advances of animal models of renal interstitial fibrosis[J]. Basic Medical Sciences and Clinics, 2006, 26(11): 1281-1285 |
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| Authors: | X Zhi-hong CHEN Yi-pu |
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| Affiliation: | 1. Graduate School of Peking Union Medical College; 2. Nephrology Center, Chinese-Japanese Friedship Hospital, Bejing 100029, China |
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| Abstract: | Renal interstitial fibrosis closely correlates with deteriotation of renal function.The experiments on animal models are necessary for studying renal interstitial fibrosis.Researchers should find right animal models according to different objectives.Research advancement of widely-used eight animal models of renal interstitial fibrosis,such as unilateral ureteral obstruction,cyclosporine A nephropathy and chronic aristolochic acid nephropathy,are reviewed in this paper. |
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| Keywords: | renal interstial fibrosis animal model |
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