| RAS系统中负向调控因子与肾纤维化的关系 |
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| 引用本文： | 于冀洋,朱光华.RAS系统中负向调控因子与肾纤维化的关系[J].医学综述,2007,13(1):56-58. |
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| 作者姓名： | 于冀洋 朱光华 |
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| 作者单位： | 上海交通大学附属儿童医院,上海,200040 |
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| 摘 要： | 肾素-血管紧张素-醛固酮系统(Renin-Aangiotensin-Aldosterone System,RAAS)中的血管紧张素Ⅱ(AngⅡ)及其相关细胞因子如转化生长因子(TGF-β)、结缔组织生长因子(CTGF)、血小板源性生长因子(PDGF)等已被大量试验证实与肾纤维化存在直接或间接关系,但近年来的研究发现肾素-血管紧张素系统(RAS)系统中的血管紧张素受体2(AT2R),血管紧张素转换酶2(ACE2),血管紧张素Ang(1-7),肝细胞生长因子(HGF)等则表现出拮抗上述物质的作用,本文就RAS系统新成员及其细胞因子对肾纤维化的作用简要综述。
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| 关 键 词： | 肾纤维化 血管紧张素转换酶2 血管紧张素受体2 肝细胞生长因子 |
| 文章编号： | 1006-2084（2007）01-0056-03 |
| 收稿时间： | 2006-04-26 |
| 修稿时间： | 2006-04-262006-12-01 |
The Relationship Between Negative Regulation Factors in RAS and Renal Fibrosis |
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| YU Ji-yang,ZHU Guang-hua.The Relationship Between Negative Regulation Factors in RAS and Renal Fibrosis[J].Medical Recapitulate,2007,13(1):56-58. |
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| Authors: | YU Ji-yang ZHU Guang-hua |
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| Abstract: | Ang Ⅱ as well as the related cell factors such as transforming growth factor(TGF-β),connective tissue growth factor(CTGF),platelet-derived growth factor(PDGF) in Renin-Aangiotensin-Aldosterone System(RAAS) has direct or indirect relationship with renal fibrosis,which has been confirmed by many tests,but the recent study shows that angiotensin receptor II,Angiotensin-Converting 2,Ang(1～7),hepatocyte growth factor(HGF) have antagonism to the substance above mentioned.This article reviews the action of these rivalry factors to renal fibrosis. |
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| Keywords: | Renal fibrosis Angiotensin-Converting II Angiotensin receptor Ⅱ Hepatocyte growth factor |
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