Relation of serum uric acid to an exaggerated systolic blood pressure response to exercise testing in men with normotension |
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| Authors: | Sae Young Jae PhD Kanokwan Bunsawat PhD Yoon‐Ho Choi MD Yeon Soo Kim MD Rhian M. Touyz MD Jeong Bae Park MD Barry A. Franklin PhD |
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| Affiliation: | 1. Department of Sport Science, University of Seoul, Seoul, South Korea;2. Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL, USA;3. Center for Health Promotion, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea;4. Department of Physical Education, Seoul National University, Seoul, South Korea;5. Institute of Cardiovascular & Medical Sciences, University of Glasgow, Glasgow, UK;6. Division of Cardiology, Cheil General Hospital, Dankook University College of Medicine, Seoul, South Korea;7. Preventive Cardiology and Cardiac Rehabilitation, William Beaumont Hospital, Royal Oak, MI, USA |
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| Abstract: | The authors investigated the hypothesis that high serum uric acid concentrations may be related to an exaggerated systolic blood pressure (SBP) response to maximal exercise testing in men with normotension, independent of potential confounding variables. In 4640 healthy men with normotension who underwent maximal treadmill exercise testing and fasting blood chemistry studies, including serum uric acid concentrations, an exaggerated SBP response, defined as SBP ≥ 210 mm Hg, was detected in 152 men (3.3%). After adjusting for potential confounders, participants in the highest quartile of serum uric acid (>6.6 mg/dL) had a higher odds ratio of demonstrating an exaggerated SBP to maximal exercise (odds ratio, 2.19; 95% confidence interval, 1.24–3.86) compared with participants in the lowest quartile of serum uric acid (<5.1 mg/dL). High serum uric acid concentrations are associated with an exaggerated SBP response to maximal exercise testing in men with normotension, independent of established coronary risk factors. |
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| Keywords: | exaggerated systolic blood pressure response exercise testing uric acid |
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