Association of mood disorders with cardiovascular disease risk factors in overweight and obese youth with elevated blood pressure |
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| Authors: | Leah Medrano MD Kaushalendra Amatya PhD Diane Vizthum MS RD Jeffrey J Fadrowski MD MHS Tammy M Brady MD PhD |
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| Institution: | 1. Johns Hopkins University School of Medicine, Baltimore, MD, USA;2. Division of Child and Adolescent Psychiatry, Children's National Medical Center, Washington, DC, USA;3. Institute for Clinical and Translational Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA;4. Division of Pediatric Nephrology, Johns Hopkins University School of Medicine, Baltimore, MD, USA |
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| Abstract: | The American Heart Association defines mood disorders (MDO) as a tier‐II cardiovascular disease risk factor in children. Cross‐sectional analysis of overweight/obese children referred to an obesity hypertension clinic revealed 37% had a MDO (defined by clinical diagnosis or Patient Health Questionnaire‐9/‐A score ≥10), 55% had confirmed hypertension, and 75% left ventricular hypertrophy (LVH). Children with MDOs were older, had greater measures of adiposity, and had a greater prevalence of hypertension (78%) than those without MDOs (42%; P = .04). Hypertensive children were 2.8 times more likely to have a MDO than those without (52% vs 18%; P = .02). Multivariable logistic regression revealed a statistically significant independent association of MDOs with hypertension (Odds Ratio OR] 6.3, P = .048), but not LVH (LVMI ≥ 51 g/m2.7; OR 1.13, P = .88). Overall, the prevalence of MDOs in this group of overweight/obese children with elevated blood pressure was well above national averages, suggesting that at‐risk youth, particularly those with confirmed hypertension, should be regularly screened for MDOs. |
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| Keywords: | adolescents cardiovascular disease children hypertension left ventricular hypertrophy mood disorders obesity overweight pediatrics |
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