| 五味子和刺五加对老年大鼠心肌环核苷酸系统的影响 |
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| 引用本文： | 陈国千,王霞文.五味子和刺五加对老年大鼠心肌环核苷酸系统的影响[J].中药药理与临床,1992(2). |
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| 作者姓名： | 陈国千 王霞文 |
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| 作者单位： | 重庆医科大学，重庆医科大学 630046 温州医学院附一院，630046 |
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| 摘 要： | 用五味子和刺五加分别喂养老年大鼠2个月,五味子显著提高心肌cAMP 含量、cAMP/cGMP比值和腺苷酸环化酶(AC)肾上腺素激活活性较基础活性的 提高率,降低cAMP磷酸二酯酶活性;刺五加显著提高钙调素含量、AC肾上腺素激 活活性及其较基础活性的提高率。提示五味子和刺五加通过环核苷酸系统途径改善 心脏功能。
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| 关 键 词： | 五味子 刺五加 环腺苷酸 环鸟苷酸 腺苷酸环化酶 磷酸二酯酶 钙调素 |
Effect of Schisandra Chinensis and Acanthopanax Senticosus on Cyclic Nacleotide System in Aged Rat Myocardium |
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| Chen Guoqian,Wang Xiawen.Effect of Schisandra Chinensis and Acanthopanax Senticosus on Cyclic Nacleotide System in Aged Rat Myocardium[J].Pharmacology and Clinics of Chinese Materia Medica,1992(2). |
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| Authors: | Chen Guoqian Wang Xiawen |
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| Institution: | Chongqing university of Medical Sciences |
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| Abstract: | The 22 months old, fats were treated with Sehisandra chineasis or Acanthopsaax sen-ticosus for 2 months. The level of cAMP and the ratio of cAMP/cGMP were markedly elevated in Schisandra chinensis group, compared with that in the control. On the other hand, the activity of cAMP-phosphodiesterase was significantly decreased.In the case of Acanthopanax seajicosus, the level of calmodulin and, the activity of epinephrinestimul-ated adenylate cyelase were markedly elevated. These results suggest Schisandra chinensis and Acanthopanax sentieosus improve cardiac function by way of cyclic nucleotide system. |
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| Keywords: | Sehisandra chinensis Acanthopanax senticosus Myoeardium Cyclic AMP Cyclic GMP Adenylate eyclase Phosphodiesterase Calmodulin |
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