急性冠脉综合征患者血清IL-7的表达水平及其对预后的影响

目的：探讨急性冠脉综合征（ACS）患者血清白细胞介素（IL）-7表达水平并分析其与预后的关系.方法：选择ACS患者130例（急性心肌梗死70例,不稳定型心绞痛60例）、稳定型心绞痛患者33例（SAP组）、健康体检者89例（健康对照组）,使用ELISA法检测各组IL-7水平并进行比较,并跟踪随访130例ACS患者的病情,通过Logistic回归分析判断IL-7水平与预后的关系.结果：与健康对照组和SAP组比较,UAP组和AMI组IL-7水平均显著升高[（1.84±0.47） pg/ml、（2.11±0.63） pg/ml比（4.87±0.52） pg/ml、（5.15±0.71） pg/ml,P＜0.05或P＜0.01],健康对照组与SAP组,UAP组与AMI组之间IL-7水平无显著差异（P均＞0.05）;Logistic回归分析显示,ACS患者血清中IL-7的水平是发生不良心血管事件的独立危险因素（OR=1.212,95％CI：1.061～1.418）.结论：白细胞介素-7作为机体重要的炎症因子之一,其水平在急性冠脉综合征患者的异常升高,可能具有判断疾病预后的重要价值.

The expression level of serum IL-7 and its influence on prognosis in patients with acute coronary syndrome

Objective： To explore the expression level of serum interleukin （IL） -7 in patients with acute coronary syndrome （ACS） and analyze the relationship between IL-7 level and prognosis. Methods： A total of 130 ACS pa- tients [AMI group, ineluding 70 cases with acute myocardial infarction （AMI） and 60 cases with unstable angina pectoris （UAP）], 33 cases with stable angina pectoris （SAP, SAP group） and 89 healthy subjects （healthy control group） were selected. IL-7 level was measured using enzyme linked immunosorbent assay （ELISA） and compared a- mong all groups. The 130 ACS patients were followed up, and Logistic regression analysis was used to analyze the re~ lationship between IL-7 level and prognosis. Results： Compared with healthy control group and SAP group, there was significant rise in IL-7 level in UAP group and AMI group [ （1.84＋--0.47） pg/ml, （2.114-0.63） pg/ml vs. （4.87＋_0.52） pg/ml, （5.15-t=0.71） pg/mh P〈0.05 or P〈0.01]. There were no significant difference in IL-7 level between healthy control group and SAP group, UAP group and AMI group （P〉0.05 both） ; Logistic regres- sion analysis indicated that expression level of serum IL-7 was an independent risk factor for adverse cardiovascular events in ACS patients （OR= 1. 212, 95% CI.. 1.061--1. 418）. Conclusion.. Interleukin-7, as an important inflam- matory cytokines, its serum level abnormally elevated in patients with acute coronary syndrome, it may have impor- tant prognostic value.