Plasma concentrations of intravenous β-methyl digoxin with and without oral charcoal

Summary Six healty male volunteers received 1.0 mg of -methyl digoxin intravenously two times at a 21 day interval. In a randomized sequence they received orally 2 g t.i.d. of activated charcoal during one of the periods. Glycoside plasma levels were determined over a 48 hour period using a⁸⁶Rb-erythrocyte-assay. During the period with charcoal, plasma levels were somewhat lower, the difference was statistically not significant. The clinical relevance of the observation remains uncertain.