Lignans from Kadsura angustifolia |
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| Authors: | Chen Y G Qin G W Xie Y Y Cheng K F Lin Z W Sun H D Kang Y H Han B H |
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| Institution: |
a Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
b Department of Chemistry, The University of Hong Kong, Hong Kong, China
c Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China
d Natural Products Research Institute, Seoul National University, Seoul, Korea |
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| Abstract: | A new dibenzocyclooctadiene lignan named angustifolin D (1) together with four known lignans: kadsulignan L (2), kadsulignan N (3), schisantherin P (4) and meso-dihydroguaiaretic acid (5) were isolated from the stems of Kadsura angustifolia. Their structures and stereochemistries were elucidated by spectral studies. Compounds 2 and 5 showed moderate plateletactivating factor (PAF) antagonistic activities with IC50 values of 2.6 × 10-5 and 4.1 × 10-5 M, respectively. |
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| Keywords: | Lignan Kadsura angustifolia Anti-PAF activities |
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