甲状腺自身抗体与复发性流产关系的初步探讨

目的 研究抗甲状腺球蛋白抗体和抗甲状腺过氧化物酶抗体与复发性流产（RSA）之间的关系。方法 2004-08—2005—10选取山东省立医院妇产科门诊100例有复发性流产史非妊娠妇女为研究组，其中原发性RSA62例（原发性RSA组），继发性RSA38例（继发性RSA组），100例有正常妊娠史非孕健康妇女为对照组，化学发光免疫法测两组血清中的抗甲状腺抗体。结果 研究组血清中抗甲状腺球蛋白抗体和抗甲状腺过氧化物酶抗体的阳性率分别为：24％和28％，明显高于对照组的4％和6％（P〈0、05）。原发性与继发性RSA患者血清中抗体阳性率差异无显著性（P〉0、05）。结论 在复发性流产患者中，甲状腺自身抗体的阳性率增高，需进一步研究治疗后对妊娠结局的影响。

A study in relationship between antithyroid antibodies and recurrent spontaneous abortion

Objective To study the relationship between antithyroglobulin antibodies,thyroperoxidase antibodies and recurrent spontaneous abortion(RSA). Methods Select 100 non-pregnant women with a history of RSA as study group,who were further divided into 2 subgroups corresponding to 62(primary RSA)and 38(secondary RSA) patients respectively; select 100 healthy women with a normal pregnant history as control group. Determine two groups' serum antithyroglobulin antibodies and thyroperoxidase antibodies by chemiluminescence immunoassay.Results Antithyroglobulin antibodies and thyroperoxidase antibodies in serum were identified in 24% and 28% of study group.Antithyroglobulin antibodies and thyroperoxidase antibodies in serum were identified in 4% and 6% of the controls. There was a prominent difference(P<0.05). Primary RSA compared with secondary RSA had no significant difference in antithyroglobulin antibodies and thyroperoxidase antibodies (P>0.05).Conclusion The results show that the antithyroid antibodies in serum may be related to RSA.