| 中药五倍子对白色念珠菌生物膜影响的体外研究 |
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| 引用本文： | 许颖,李福明. 中药五倍子对白色念珠菌生物膜影响的体外研究[J]. 黑龙江医药科学, 2008, 31(4) |
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| 作者姓名： | 许颖 李福明 |
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| 作者单位： | 佳木斯大学附属口腔医院牙体牙髓病科,黑龙江,佳木斯,154002 |
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| 基金项目： | 黑龙江省教育厅科学技术研究项目 |
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| 摘 要： | 目的:比较五倍子水煎液、氢氧化钙和洗必泰三种根管消毒药物对白色念珠菌生物膜作用效果。方法:在96孔培养板底形成白色念珠菌生物膜,用XTT减低法定量分析生物膜形成过程及三种药物抑制生物膜内细胞生长80%的药物浓度。结果:48h细胞代谢水平最高,细胞活力及耐药性随培养时间延长而增强。结论:白色念珠菌生物膜对氢氧化钙耐药,对洗必泰敏感,五倍子对白色念珠菌生物膜初期阶段具有抑制作用。
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| 关 键 词： | 五倍子 白色念珠菌生物膜 XTT减低法 |
Effect of Galtnut on Candida albicans biofilm:An in vitro study |
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| XU Ying,LI Fu-ming. Effect of Galtnut on Candida albicans biofilm:An in vitro study[J]. Heilongjiang Medicine and Pharmacy, 2008, 31(4) |
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| Authors: | XU Ying LI Fu-ming |
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| Abstract: | Objective:To compare the effects of aqueous extract of Chinese Galtnut,calcium hydroxide and chlorhexidine on candida albicans biofilm.Methods:Biofilms were grown on 96-well polymethylmethacrylate strips,and the quantitative analysis of biofilm formation and the concentrations of three antimicrobials restraining 80% fungal growth was performed by XTT reduction method.Result:The cellular metabolism level at 48h was the highest.The biofilm bioactivity and drug resistance increased with culturing time.Conclusion:Candida albicans were unsensitive to calcium hydroxide but sensitive to chlorhexidine and aqueous extract of Chinese Galtnut can restrain the biofilm formation at the initial stage. |
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| Keywords: | galtnut candida albicans biofilm XTT reduction method |
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